| 基因乙肝疫苗接种母鸡的体液免疫应答 |
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| 引用本文： | 徐燕萍,湛学军,杨淑华,谢大泽,胡昕. 基因乙肝疫苗接种母鸡的体液免疫应答[J]. 江西医学院学报, 2002, 42(5): 26-27 |
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| 作者姓名： | 徐燕萍 湛学军 杨淑华 谢大泽 胡昕 |
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| 作者单位： | 江西省医学科学研究所，江西南昌330006 |
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| 摘 要： | 目的：探讨基因乙肝疫苗对母鸡免疫效果的影响。方法：用基因乙肝疫苗辅以佐剂皮下注射母鸡，随后加强免疫4次，用ELISA方法检测血清中抗－HBs。结果：在初次免疫母鸡血清中检出低滴度抗体，加强免疫后，抗体水平显著上升，滴度高达1：640，并维持较长时间，其抗体水平及抗体应答持久性与注射次数与注射途径有关。此外，用乙肝疫苗加佐剂比单用乙肝疫苗免疫效果明显要好。结论：应用基因乙肝疫苗能够诱导母鸡产生针对HBsAg的特异性体液免疫应答。
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| 关 键 词： | 乙型肝炎疫苗 基因 抗体 母鸡 |
| 文章编号： | 1000-2294(2002)05-0026-02 |
| 修稿时间： | 2002-07-10 |
Humoral Immune Response to Gene Hepatitis B Vaccines in Vaccinated Chicken |
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| XU Yan-ping,ZHAN Xue-jun,YANG Shu-hua,XIE Da-ze,HU xin. Humoral Immune Response to Gene Hepatitis B Vaccines in Vaccinated Chicken[J]. Acta Academiae Medicinae Jiangxi, 2002, 42(5): 26-27 |
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| Authors: | XU Yan-ping ZHAN Xue-jun YANG Shu-hua XIE Da-ze HU xin |
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| Abstract: | Objective: To study the effect of hepatitis B vaccine immunization in the chicken. Methods:Chicken were injected subcutaneously with hepatitis B gene vaccines with subsidiary adjuvant.Antibodies against HBsAg were detected with ELISA.Results:Low antibody titers were observed following primary immunization. After four time of booster immunization,anti-HBs titers increased remarkably up to 1:640 and developed long-lasting immunity. The level of antibody response and long-lasting immunity was related to the number and routes of hepatitis B vaccines of doses injected. In addition,Hepatitis B vaccines with adjuvant was more effective than that without one. Conclusion: This result indicated that the hepatitis B gene vaccine can induce specific humoral immune response to HBsAg in the chicken. |
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| Keywords: | hepatitis b vaccines gene antibody chicken |
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