N-nitroso-N-methyloctadecylamine in hair-care products |
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| Authors: | J B Morrison S S Hecht J A Wenninger |
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| Affiliation: | Division of Chemical Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY 10595, USA;Division of Cosmetics Technology, Food and Drug Administration, Department of Health and Human Services, Washington, DC 20204, USA |
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| Abstract: | Fifty-three cosmetic products containing one or more of the ingredients N,N-dimethyloctadecylamine oxide, N,N-dimethyloctadecylamine and N-benzyl-N,N-dimethyloctadecylammonium chloride were analysed for N-nitroso-N-methyloctadecylamine by gas chromatography with detection by a Thermal Energy Analyzer. [1-14C]N-Nitroso-N-methyloctadecylamine was used as an internal standard. Eight of 11 products containing N,N-dimethyloctadecylamine oxide and three of 38 products containing N-benzyl-N,N-dimethyloctadecylammonium chloride were found to contain N-nitroso-N-methyloctadecylamine at levels ranging from 28 to 969 ppb. In photolysis experiments, all of these products exhibited a loss of Thermal Energy Analyzer response for N-nitroso-N-methyloctadecylamine following irradiation by ultraviolet light. In two cases, the presence of N-nitroso-N-methyloctadecylamine was confirmed by combined gas chromatography-mass spectrometry. |
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| Keywords: | NDELA NMODA |
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