A correlative evaluation of cyclazocine,LSD and naloxone on continuous discriminated avoidance in rats |
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Authors: | Samuel R Wray |
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Institution: | (1) Department of Psychology, University of Hull, HU6 7RX Hull, England |
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Abstract: | Cyclazocine, a long acting narcotic antagonist, induces disorientation, hyperirritability and hallucinations. In contrast, naloxone is devoid of any psychotomimetic affects. Cyclazocine (2.5 mg/kg) and LSD (1.0 mg/kg) induced strikingly similar behavioural disruptions on well-established discriminated (Sidman) avoidance performance in rats. Cyclazocine and LSD administration resulted in periods of response-inhibition and a subsequent enhancement of response rates. In the presence of the warning signal rats often failed to lever-press and as a consequence received more shocks. Naloxone (30 mg/kg) had little effect on avoidance responding. The effects of cyclazocine and LSD in rats may be mediated through similar mechanisms. |
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Keywords: | Cyclazocine LSD Naloxone Response-Excitation Psychotomimetics Discriminative Avoidance Conditioning |
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