肝星状细胞在肝脏疾病中的作用

肝星状细胞（HSC）是肝脏内重要的非实质细胞之一，可分泌、释放多种胶原纤维和细胞骨架蛋白参与肝脏疾病的病理生理过程。正常状态下，HSC通过调节细胞外基质蛋白的合成和降解维持肝脏正常的组织结构；肝脏损伤时，HSC被激活，活化的HSC导致细胞外基质的增加是肝纤维化形成并最终导致肝硬化、肝衰竭的主要原因。因此，深入研究HSC在肝脏疾病发生与发展中的作用和机制，并研究与HSC相关的治疗策略，对于提高患者生存率具有一定意义。

Effects of hepatic stellate cells in hepatic diseases

Hepatic satellite cell （HSC） is a kind of nonparenchymal cells in the liver, which releases various collagenous fibers and cytoskeletal proteins, playing an important role in the pathophysiological changes of the liver. In normal, HSCs maintain normal tissue architecture via regulating the synthesis and degradation of extraeellular matrix （ECM） proteins. During liver injury, HSCs were activated. Activated HSCs are the main cells that lead to the accumulation of extracellular matrix, which is the main reason of hepatic fibrosis, cirrhosis and liver failure. Therefore, lueubrating the role and mechanism of HSC in the progress of hepatic disease and investiating the HSC-related therapeutic strategies have practical siguificances for the prevention and treatment of liver injury and raise of patients＇ survival rates in clinical practice.