| 二乙基亚硝胺诱发大鼠肝癌癌变过程中肝细胞超微结构的变化 |
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| 引用本文： | 沈儒龙,薛婉芬,徐秉栋,高达.二乙基亚硝胺诱发大鼠肝癌癌变过程中肝细胞超微结构的变化[J].南京医科大学学报,1987(3). |
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| 作者姓名： | 沈儒龙 薛婉芬 徐秉栋 高达 |
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| 作者单位： | 南京医学院病理解剖学教研室，南京医学院病理解剖学教研室，南京医学院病理解剖学教研室，南京医学院病理解剖学教研室 |
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| 摘 要： | 报道二乙基亚硝胺诱发Sprague-Dawley(SD)大鼠肝癌发生过程中肝细胞超微结构的动态改变。发现早在肉眼和光镜发现肿瘤之前,肝细胞就发生了一系列超微结构改变,且观察到卵圆细胞向高度嗜硷性肝细胞、肝细胞肝癌转化的连续变化谱。
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| 关 键 词： | 肝癌 超微结构 二乙基亚硝胺 鼠 |
THE ULTRASTRUCTURAL CHANGES OF LIVER DURING CARCINOGENESIS IN DIETHYLNITROSAMINE-FED RATS |
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| Shen Lulong,et al..THE ULTRASTRUCTURAL CHANGES OF LIVER DURING CARCINOGENESIS IN DIETHYLNITROSAMINE-FED RATS[J].Acta Universitatis Medicinalis Nanjing,1987(3). |
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| Authors: | Shen Lulong |
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| Abstract: | This study investigates the ultrastructural changes of hepatocytes during hepatocarcinogenesis in Sprague-Dawley rats fed with diethylnitrosamine(DEN). The liver cells underwent a series of ultrastructural changes before they became light microscopically demonstrable malignant cells. Occurrence of these transitional changes in oval cells strongly indicates that the oval cells may be the precursor of hepatoma. |
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| Keywords: | hepatocarcinoma ultrastructure diethylnitrosamine rats |
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