| 福定碱对胆碱酯酶的抑制特点 |
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| 引用本文： | 宫泽辉,秦伯益. 福定碱对胆碱酯酶的抑制特点[J]. 军事医学科学院院刊, 1986, 0(6) |
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| 作者姓名： | 宫泽辉 秦伯益 |
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| 作者单位： | 军事医学科学院药理毒理研究所，军事医学科学院药理毒理研究所 |
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| 摘 要： | 福定碱是一新结构类型的可逆性胆碱酯酶抑制剂。它具有较强的拟胆碱作用。对小鼠脑、红细胞和猪脑固相胆碱酯酶(AChE)的抑制强度为对血浆胆碱酯酶(BuChE)抑制强度的数千倍。体内对小鼠AChE的抑制时间远比氨基甲酸酯类化合物催醒宁(二甲氨基甲酸-5-(1,3,3-三甲基)吲哚满酯盐酸盐(TIDC)长。抑酶方式属竞争和非竞争性的混合型抑制。
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| 关 键 词： | 福定碱 催醒宁 AChE BuChE 可逆性 ChE抑制剂 选择性 混合性抑制剂 |
THE INHIBITORY CHARACTERISTICS OF FORDINE ON CHOLINESTERASES |
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| Gong Zehui Qin Boyi. THE INHIBITORY CHARACTERISTICS OF FORDINE ON CHOLINESTERASES[J]. Bulletin of the Academy of Military Medical Sciences, 1986, 0(6) |
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| Authors: | Gong Zehui Qin Boyi |
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| Abstract: | Fordine, a reversible ChE inhibitor with a new structure, acts as a potent cholinomimetic drug. In vitro, the inhibitory potency of fordine on mouse brain or erythrocyte AChE and on porcine brain immobilized AChE was thousand times higher than that on BuChE in the blood and serum of mouse. In vivo, the recovery of mouse AChE inhibited by fordine was significantly delayed than that inhibited by CuiXingNing. The inhibition of ChE by fordine showed a mixed pattern of both competitive and non-competitive inhibitions. Fordine showed a higher selective inhibition on AChE than on BuChE. |
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| Keywords: | fordine Cui Xing Ning AChE BuChE reversible ChE inhibitor selectivity mixed inhibitor |
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