鱼油n-3脂肪酸对兔血小板聚集的抑制作用

为比较鱼油和玉米油在有猪油存在时的抗血小板聚集作用,将大白兔分为鱼油、玉米油和猪油3组。3组饲料除含2.5％猪油,再分别加3.5％的鱼油、玉米油和猪油,喂兔12周。第3周后,鱼油组兔血小板脂肪酸组成中++碳五烯酸(EPA)含量即高,第9周达10％,而玉米油和猪油组只含EPA0.17～0.40％;EPA和花生四烯酸比值,鱼油组为0.49～0.92,玉米油和猪油组为0.02～0.03。第6周后,全血和富含血小板血浆中的血小板聚集性,鱼油组显著低于另2组(P<0.05)。表明在同时进食猪油时,鱼油能抑制兔血小板聚集,玉米油不具这一作用。

Inhibitory Effect of n-3 Fatty Acids of Fish Oil on Platelet Aggregation in Rabbits

To compare the effects on the platelet aggregation of fish oil and corn oil taken in together with lard,three groups of rabbits were fed on the chow containing 2.5% of lard with an addition of 3.5% of fish oil,corn oil and lard respectively for twelve weeks.The eicosapentaenoic acid in platelet was 10% higher in fish oil group than in the other two groups.The ratio of eicosapentaenoic acid/arachidonic acid was 0.49-0.92 in fish oil group,but 0.02-0.03 in the other two groups.Six weeks later the platelet aggregation in both whole blood and platelet-rich plasma was significantly lower in fish oil group than in corn oil and lard groups (P<0.05).These results suggest that fish oil rather than corn oil can inhibit rabbit platelet aggregation even in the presence of lard which is thought to be pro-aggregatory.