硫普罗宁对化疗药物所致肝损伤的治疗作用

目的观察硫普罗宁对化疗药物所致轻度肝损伤的治疗作用。方法将采用化疗药物化疗后有轻度肝损伤的44例恶性肿瘤患者随机分为治疗组和对照组。治疗组22例加硫普罗宁静脉滴注,对照组22例用肝泰乐、益肝灵常规保肝药口服,观察治疗前后丙氨酸转氨酶(ALT)的变化。结果治疗组治疗后ALT值显著低于治疗前,与对照组比较差异有显著性(P<0.01)。结论硫普罗宁可对抗化疗药物所致轻度肝损伤作用,保证化疗连续性。

Protective effect of tiopronin on liver injury caused by chemotherapeutics

Objective To observe the protective role of Tiopronin on hepatic injury caused by chemotherapeutics.Methods Forty-four patients with cancer,who suffered from slight liver injury after chemotherapy were divided into treated group and control group, each 22 patients. In control group, the routine liver-protective agents such as glucurolactone and silymarill were used only, whereas Tiopronin was additionally added in therapy group. The change of ALT was observed before and after therapy so as to determine agents' effectiveness of Tiopronin.Results The serum level of ALT in the treated group after liver-protective treatment with Tiopronin was obviously lower than that of control group (P<0.01).Conclusion Tiopronin has significantly effect to inhibit hepatic injury after chemotherapy in the patients with cancer, and can effective maintenance the continuity of chemotherapy.