原发性血小板增多症血小板更新率与血栓形成的关系

为了对原发性血小板增多症血小板更新率(turnover)变化与血栓形成的关系进行分析,根据有无血栓症状将26例原发性血小板增多症(ET)患者分成两组,应用流式细胞术检测网织血小板(RP),选择26名健康献血者作为对照。应用羟基脲加α-干扰素对血栓病例进行治疗。结果表明:有血栓ET病例的RP百分数(14.8%±7·2%)比无症状病例的(4.5%±2.3%)和健康对照的(3.3%±1.5%)显著增高(P<0.05);RP百分数在无血栓病例和健康对照中无差异。有血栓病例的RP绝对值比无血栓病例显著升高[(176±37)×109/Lvs(46±12)×109/L]。有血栓ET病例接受羟基脲加α-干扰素治疗后,RP百分数和绝对数均明显降低(P<0.05)。结论:ET病例形成血栓时,与无血栓病例和健康对照相比,其RP百分数和绝对数均显著升高,有血栓的ET患者用羟基脲加α-干扰素治疗疗效良好。

Correlation of Thrombosis with Increased Platelet Turnover in Essential Thrombocythemia

This study was aimed to investigate the correlation of thrombosis with increased platelet turnover in essential thrombocythemia. According to presence or absence of thrombosis, 26 patients with ET were divided into two groups. Reticulated platelets (RP) were measured by flow cytometry and 26 healthy volunteers were selected as healthy controls. The ET patients with thrombosis were treated with hydroxyurea and interferon-alpha. The results demonstrated that the ET patients with thrombotic events had a significantly higher RP percentage (14.8% +/- 7.2%) than that in both asymptomatic ET patients (4.5% +/- 2.3%) and normal control (3.3% +/- 1.5%), (P < 0.05); the RP percentage in asymptomatic ET patients did not differ significantly from controls. ET patients with thrombosis also had a significantly higher absolute RP (ARP) count than those in ET patients without thrombosis [(176 +/- 37) x 10(9)/L vs (46 +/- 12) x 10(9)/L]. The ET patients with thrombosis were successfully treated with hydroxyurea plus INF-alpha, the RP percentage and ARP counts obviously reduced. In conclusion, when the ET patients had thrombotic events, those patients had a significantly higher RP percentage and ARP compared with patients without thrombosis and healthy controls. The ET patients with thrombosis were successfully treated with hydroxyurea plus INF-alpha.