| 血管紧张素转化酶基因多态性与Ⅱ型糖尿病肾病 |
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| 引用本文： | 赵长霞,胡东南,谢翠鹏,胡逢来,章士娜,张霞. 血管紧张素转化酶基因多态性与Ⅱ型糖尿病肾病[J]. 中国现代医药杂志, 2001, 3(2): 35-37 |
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| 作者姓名： | 赵长霞 胡东南 谢翠鹏 胡逢来 章士娜 张霞 |
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| 作者单位： | 1. 100076,北京,中国航天科技集团公司总医院检验科
2. 100076,北京,中国航天科技集团公司总医院内科 |
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| 摘 要： | 目的探讨血管紧张素转化酶(ACE)基因插入/缺失多态性与Ⅱ型糖尿病(NIDDM)肾病的关系。方法聚合酶链反应。结果无肾病的NIDDM患者中 ,ACE基因型频率与正常人比较 ,I/I基因型和I/D D/D基因型频率分布差异有显著性意义(P<0.05) ;有肾病的NIDDM患者中 ,ACE基因型频率与正常人比较 ,D/D基因型和I/D I/I基因型频率分布差异有显著性意义(P<0.05)。结论I/I基因型是NIDDM肾病患者的保护性基因 ;而D/D基因型是NIDDM肾病患者的易感基因
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| 关 键 词： | 血管紧张素转化酶 基因多态性 Ⅱ型糖尿病肾病 相关性 |
| 修稿时间： | 2000-02-10 |
Relationship between polymorphism of angiotensin converting enzyme gene and NIDDM nephropathy |
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| Zhao Changxia,Hu Dongnan,Xie Cuipeng,et al.. Relationship between polymorphism of angiotensin converting enzyme gene and NIDDM nephropathy[J]. Modern Medicine Journal of China, 2001, 3(2): 35-37 |
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| Authors: | Zhao Changxia Hu Dongnan Xie Cuipeng et al. |
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| Affiliation: | Zhao Changxia,Hu Dongnan,Xie Cuipeng,et al. General Hospital of CASTGC,Beijing 100076 |
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| Abstract: | Objective To study the relationship between the ACE gene polymorphism and non_insulin dependent Diabetes Mellitis nephropathy. Methods Polymerase chain reaction(PCR). Results In patients with non_NIDDM_nephropathy, comparing to normal group, the I/I genotype and I/D D/D genotype frequency distribution difference is significant(P<0.05); and the D/D genotype and I/D I/I genotype frequency distribution difference is also significant(P<0.05). Conclusion I/I genotype is a protecting factor for NIDDM nephropathy. And D/D genotype is a risk factor for NIDDM nephropathy. |
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| Keywords: | ACE Gene_polymorphism NIDDM_nephropathy Relationship |
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