Met-Independent Hepatocyte Growth Factor-mediated regulation of cell adhesion in human prostate cancer cells |
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| Authors: | Amanda Tate Shuji Isotani Michael J Bradley Robert A Sikes Rodney Davis Leland WK Chung Magnus Edlund |
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| Affiliation: | (1) Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA;(2) Department of Biological Sciences, University of Delaware, Newark, DE, USA;(3) Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA |
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| Abstract: | Background Prostate cancer cells communicate reciprocally with the stromal cells surrounding them, inside the prostate, and after metastasis, within the bone. Each tissue secretes factors for interpretation by the other. One stromally-derived factor, Hepatocyte Growth Factor (HGF), was found twenty years ago to regulate invasion and growth of carcinoma cells. Working with the LNCaP prostate cancer progression model, we found that these cells could respond to HGF stimulation, even in the absence of Met, the only known HGF receptor. The new HGF binding partner we find on the cell surface may help to clarify conflicts in the past literature about Met expression and HGF response in cancer cells. |
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