早泄药物治疗进展

早泄是最常见的性功能障碍之一,对患者生活质量产生重要影响。多年来行为疗法在早泄治疗中占主要地位,但患者较难控制,长期效果也不满意。目前常用的治疗早泄药物包括阴茎局部用药、5型磷酸二酯酶抑制剂和5羟色胺再吸收抑制剂,但临床应用有限。开发按需使用、耐受性好、快速起效、快速清除的口服药物是今后研究的方向。现对早泄药物治疗及进展进行综述,为临床用药提供参考。

Update of Pharmacotherapy for Premature Ejaculation

Premature ejaculation(PE)is one of the most common sexual dysfunction problems,which has significant adverse effects on the life quality of the patients.Behavioral therapies have been the mainstay of PE management for many years.However,there is inadequate evidence for their long-term benefit.There are currently no medications licensed specifically for the treatment of PE.Current "off-label" pharmacotherapeutic approaches include topical anesthetics,phosphodiesterase-5 inhibitors,and serotonin reuptake inhibitors,all of which,however,fall short of the ideal therapy for PE.In the absence of a cure,the ideal treatment that researches aim at should be tolerable,effective from the first dose,rapid in onset of action,fast in elimination,and available as an oral medication.It is anticipated that agents being developed for the specific indication of PE will come closer to this ideal than the existing pharmacotherapeutic approaches.