多系统萎缩患者生活质量调查及其影响因素分析

目的了解多系统萎缩(multiple system atrophy,MSA)患者生活质量的现状,并分析其主要影响因素。方法采用便利抽样法选取2010年9月至2012年7月在江苏省某三级甲等专科医院运动障碍门诊随访的MSA患者52例,采用一般资料调查表、中文版健康状况调查量表(36-item short form,SF-36)、统一多系统萎缩评估量表(unified MSA rating scale,UMSARS)、日常生活活动能力(activitiy of daily living,ADL)量表、家庭关怀指数问卷(adaptation,partnership,growth,affection and resolve,APGAR)等对MSA患者进行调查。结果各年龄组MSA患者的生活质量得分均低于正常人群;SF-36量表的8个维度中,生理功能得分最低;患者的年龄、病程、UMSARS评分与SF-36的8个维度均呈负相关(均P0.05),ADL、APGAR得分与SF-36的8个维度呈正相关(均P0.05)。影响MSA患者生活质量心理社会领域的主要因素依次为疾病了解程度、有无规律锻炼、UMSARS总分、有无慢性疾病、婚姻状况;影响生理领域的主要因素依次为疾病了解程度、UMSARS总分、有无慢性疾病、婚姻状况。结论 MSA患者的生活质量较正常人群明显下降,影响因素包括人口学因素、健康行为因素、疾病相关因素及家庭和社会支持等因素。

Study on Quality of Life and Its Influencing Factors in Patients with Multiple System Atrophy

Objective To understand the multiple system atrophy patient quality of life（MSA-QOL）status and analyze main effect factors of MSA-QOL.Methods By convenience sampling,52 patients were ran-domly selected and investigated by using the general information questionnaire,Medical outcome study （MOS SF-36）,Unified multiple system atrophy rating scale （UMSARS）,Activity of Daily Living Scale （ADL）and Family APGAR Index（APGAR）.Results Compared with the normal population,patients in all age groups MSA QOL scores were lower than the norm.Among eight dimensions of SF-36 PF ,physiological function scores lowest .The patients’age,duration,UMSARS score and SF-36 ’s eight dimensions were negatively correlated.ADL,APGAR score and SF-36 ’s eight dimensions were positively correlated.The main factors of influencing MSA-QOL psychosocial were the level of understanding the disease,with or without regular exercise,UMSARS score,with or without chronic illness,marital status.Major impact factors in the field of physiology were,in order,the level of understanding of disease,without chronic illness,marital status. Conclusion MSA-QOL than the normal population’s has declined markedly.Influence factors of MSA-QOL include demographic factors,health behavioral factors,disease-related factors ,family and social support and other factors.