Percutaneous Image-Guided Cryoablation in Inoperable Extra-abdominal Desmoid Tumors: A Study of Tolerability and Efficacy |
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Authors: | M Havez N Lippa S Al-Ammari M Kind E Stoeckle A Italiano A Gangi O Hauger F Cornelis |
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Institution: | 1. Department of Radiology, H?pital Pellegrin, CHU de Bordeaux, Place Amélie Raba Léon, 33076, Bordeaux, France 2. Department of Radiology, Institut Bergonié, 229 cours de l’Argonne, 33076, Bordeaux, France 3. Department of Surgery, Institut Bergonié, 229 cours de l’Argonne, 33076, Bordeaux, France 4. Department of Oncology, Institut Bergonié, 229 cours de l’Argonne, 33076, Bordeaux, France 5. Department of Radiology, H?pital Civil, CHU de Strasbourg, 1 place de l’H?pital, 67091, Strasbourg, France
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Abstract: | Objective To determine the tolerability, effectiveness and outcomes of percutaneous image-guided cryoablation on inoperable extra-abdominal desmoid tumors. Methods Between 2011 and 2012, 13 patients (mean age 39.3 years, range 15–74) with inoperable extra-abdominal desmoid tumors were consecutively treated with cryoablation (17 tumors treated in 17 procedures), including two patients with Gardner syndrome and nine recurrences after surgery. Disease-free survival (DFS) and local control based on RECIST criteria were calculated on prospective clinical and imaging follow-up until 2013. Results Cryoablation was performed under ultrasound (n = 8), computed tomography (n = 1), or combined (n = 8) guidance, and under general (n = 15) or local (n = 2) anesthesia. A major complication was observed in one session (5.8 %). Mean follow-up was 11.3 months (6–27 months). Among all the patients treated, eight patients (47 %) presented residual tumors on the first magnetic resonance follow-up, which were asymptomatic. The DFS rate was stable at 82.3 % (95 % confidence interval 0.55–0.94) at 6, 12, and 24 months. The local tumor progression rate was 0 % at 6, 12, and 24 months. Two patients (12 %) presented an in situ recurrence. Conclusions Despite high rates of partial ablation, percutaneous image-guided cryoablation appears to be safe and effective for local control for patients with inoperable extra-abdominal desmoid tumors. |
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