糖皮质激素对原发性肾病综合征患儿社交焦虑与攻击行为的影响

目的评估肾病综合征(nephrotic syndrome,NS)患儿在应用糖皮质激素后的社交焦虑和攻击性行为特点。方法采用便利抽样法选取2011年6月至2012年6月在东阳市人民医院治疗的NS患儿38例,应用儿童社交焦虑问卷、BussPerry攻击问卷于患儿激素治疗前(T1)、诱导缓解结束时(T2)、泼尼松1mg/(kg·d)隔日时(T3)、泼尼松0.5mg/(kg·d)隔日时(T4)进行社交焦虑水平和攻击性行为评估。结果 4个时点的社交焦虑评分、攻击性行为评分差异具有统计学意义(均P0.05),其中T2、T3、T4时点的评分均高于基线T1的评分。直线相关分析表明,社交焦虑评分、攻击性行为评分与泼尼松剂量呈正相关(均P0.05)。结论 NS患儿在长期应用糖皮质激素后,社交焦虑水平升高,攻击性行为增强,因此护理人员及患儿家长需加强相关认知和护理,为NS患儿的康复营造一个良好的身心环境。

Effects on Social Anxiety and Aggressive Behavior of Glucocorticoids in Children with Primary Nephrotic Syndrome

Objective To assess the characteristics of social anxiety and aggressive behavior in receiving hormone therapy children with nephrotic syndrome（NS）.Methods By convenience sampling,38 cases of children with NS were selected and their social anxiety and aggressive behavior were assessed by using Children’s Social Anxiety Questionnaire and Buss-Perry Aggression Questionnaire were applied to assess social anxiety levels and aggressive behavior before treatment（T1）,the end of remission phase（T2）,the day after using 1 mg/kg/d prednisone（T3）and the day after using 0.5 mg/kg/d prednisone（T4）.Results Social anxiety score and aggressive behavior score were significantly different between the four measures （all P〈0.05）,and T2,T3,T4 scores were higher than the baseline of T1 score.Linear correlation analysis showed that social anxiety score and aggressive behavior score were positively correlated with the dose of prednisone（all P〈0.05）.Conclusion Levels of social anxiety and aggressive behavior in NS children treated with glucocorticoids for a long time were enhanced,which requires nurses and parents to raise awareness and care in order to promote a better physical and psychological rehabilitation of children.