STAT3和p38MAPK在胃癌中的表达及临床意义

目的]探讨STAT3和p38MAPK在胃癌中的表达及临床意义.方法]采用免疫组化法检测80例胃癌组织及40例癌旁组织中STAT3和p38MAPK的表达.结果]80例胃癌组织中STAT3的阳性表达率为72.5％,明显高于癌旁组织的17.5％ (P＜0.001); STAT3的表达与胃癌患者性别、年龄、浸润深度无关(P＜0.05),而与分化程度、淋巴结转移、TNM分期、远处转移有关(P＜0.001).80例胃癌组织中p38MAPK的阳性表达率为71.3％,明显高于癌旁组织的12.5％(P＜0.05)；p38MAPK的表达与胃癌患者性别、年龄、淋巴结转移无关(P＞0.05),而与分化程度、浸润深度、TNM分期、远处转移有关(P＜0.001).胃癌中STAT3和p38MAPK的表达呈正相关(r=0.6986,P＜0.01).结论]胃癌中STAT3和p38MAPK均过表达,可能与胃癌的发生发展有关.

The Expression of STAT3 and p38MAPK in Gastric Cancer and its Clinical Significance

Purpose] To investigate the expression of STAT3 and p38MAPK in gastric cancer and its clinical significance.Methods] The expression of STAT3 and p38MAPK in tissue samples from 80 cases with gastric cancer and 40 cases with cancer adjacent tissues were detected by immunohistochemical method.Results] The positive rate of STAT3 in 80 cases with gastric cancer tissue was significantly higher than that in cancer adjacent tissues(72.5% vs 17.5%,P<0.001).The expression of STAT3 in gastric cancer did not relate to age,gender and invasive depth(P>0.05),but relate to differentiation,TNM staging,lymph node metastasis and distant metastasis(P<0.001).The positive rate of p38MAPK in 80 cases with gastric cancer was significantly higher than that in cancer adjacent tissues(71.3% vs 12.5%,P<0.05).The expression of p38MAPK in gastric cancer did not relate to age,gender and lymph node metastasis(P>0.05),but relate to differentiation,invasive depth,TNM staging and distant metastasis(P<0.001).There was a positive correlation between STAT3 and p38MAPK expression(r=0.6986,P<0.01).Conclusion] Over expression of STAT3 and p38MAPK might be correlated to carcinogenesis in gastric cancer.