STAT3和p38MAPK在胃癌中的表达及临床意义 |
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引用本文: | 邓立力,赵玉莹,姜秋颖.STAT3和p38MAPK在胃癌中的表达及临床意义[J].中国肿瘤,2012,21(5):383-386. |
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作者姓名: | 邓立力 赵玉莹 姜秋颖 |
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作者单位: | 1. 哈尔滨医科大学附属第二医院,黑龙江哈尔滨,150086 2. 哈尔滨医科大学附属第四医院,黑龙江哈尔滨,150001 3. 河南省肿瘤医院,河南郑州,450003 |
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基金项目: | 哈尔滨医科大学附属第二医院青年基金(QN2006-20) |
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摘 要: | 目的]探讨STAT3和p38MAPK在胃癌中的表达及临床意义.方法]采用免疫组化法检测80例胃癌组织及40例癌旁组织中STAT3和p38MAPK的表达.结果]80例胃癌组织中STAT3的阳性表达率为72.5%,明显高于癌旁组织的17.5% (P<0.001); STAT3的表达与胃癌患者性别、年龄、浸润深度无关(P<0.05),而与分化程度、淋巴结转移、TNM分期、远处转移有关(P<0.001).80例胃癌组织中p38MAPK的阳性表达率为71.3%,明显高于癌旁组织的12.5%(P<0.05);p38MAPK的表达与胃癌患者性别、年龄、淋巴结转移无关(P>0.05),而与分化程度、浸润深度、TNM分期、远处转移有关(P<0.001).胃癌中STAT3和p38MAPK的表达呈正相关(r=0.6986,P<0.01).结论]胃癌中STAT3和p38MAPK均过表达,可能与胃癌的发生发展有关.
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关 键 词: | 胃癌 STAT3 p38MAPK 免疫组化 |
收稿时间: | 2012/1/30 0:00:00 |
The Expression of STAT3 and p38MAPK in Gastric Cancer and its Clinical Significance |
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Institution: | DENG Li-li1,ZHAO Yu-ying2,JIANG Qiu-ying1,et al.(1.The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China;2.The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China) |
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Abstract: | Purpose] To investigate the expression of STAT3 and p38MAPK in gastric cancer and its clinical significance.Methods] The expression of STAT3 and p38MAPK in tissue samples from 80 cases with gastric cancer and 40 cases with cancer adjacent tissues were detected by immunohistochemical method.Results] The positive rate of STAT3 in 80 cases with gastric cancer tissue was significantly higher than that in cancer adjacent tissues(72.5% vs 17.5%,P<0.001).The expression of STAT3 in gastric cancer did not relate to age,gender and invasive depth(P>0.05),but relate to differentiation,TNM staging,lymph node metastasis and distant metastasis(P<0.001).The positive rate of p38MAPK in 80 cases with gastric cancer was significantly higher than that in cancer adjacent tissues(71.3% vs 12.5%,P<0.05).The expression of p38MAPK in gastric cancer did not relate to age,gender and lymph node metastasis(P>0.05),but relate to differentiation,invasive depth,TNM staging and distant metastasis(P<0.001).There was a positive correlation between STAT3 and p38MAPK expression(r=0.6986,P<0.01).Conclusion] Over expression of STAT3 and p38MAPK might be correlated to carcinogenesis in gastric cancer. |
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Keywords: | gastric cancer STAT3 p38MAPK |
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