我院902例药物不良反应报告分析

目的了解我院药品不良反应/事件(ADR/ADE)发生的情况及特征。方法对我院2006年7月~2010年12月收集上报的902例ADR/ADE报告,分别从患者性别及年龄,严重ADR的发生率,ADR/ADE累及系统-器官及主要临床表现,用药途径及诱发ADR/ADE的药品等方面进行统计分析。结果 902例ADR中,有447例(49.6%)是由抗菌药物引起的。其中阿奇霉素是引起ADR的最多的药物(占31.47%),抗菌药物的不良反应累及最多的是皮肤。药物-药物不良反应之间的关系能确定的有79%,撤药后恢复率达到95%。结论在我院的住院患者中,抗菌药物的使用是ADR发生的最常见的诱因,应合理应用抗菌药物,注意监测严重不良反应的发生。

Analysis of 902 adverse drug reaction reports in our hospital

Objective To understand the condition and the characteristic of adverse drug reaction/event. Methods Analyzed the adverse drug reactions(ADRs) associated with antibiotics therapy and reported from Jul 2006 to Dec 2010, in clinical notes of our hospital. We analyze the data from the patients’ sex, age, incidence of serious ADR, system-organ involved in ADR/ADE, main clinical situation, route of administration and drugs induced ADR/ADE. Results Antibiotics were responsible for 447 cases (49.6%)episodes of ADRs. Azithromycin was the drug most involved in ADRs (31.47%), and skin was the body system most susceptible to ADRs induced by all antibiotics. We determined that the drug-ADR relationship was certain in 79% of the reports; withdrawal of the suspected drug led to recovery in 95%. Conclusion Antibiotics was a common cause of ADRs in hospitalised patients,therefore,drug surveillance can successfully identify adverse events related with drug administration in hospitalised patients.