Genetic and Environmental Influences on the Covariation Between Hyperactivity and Conduct Disturbance in Juvenile Twins |
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| Authors: | Judy Silberg Michael Rutter Joanne Meyer Hermine Maes John Hewitt Emily Simonoff rew Pickles Rolf Loeber Lindon Eaves |
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| Affiliation: | Medical College of Virginia, Virginia Commonwealth University, Richmond, U.S.A.;Institute of Psychiatry, London, U.K.;Medical College of Virginia, Virginia Commonwealth University, Richmond, U.S.A.;Institute for Behavioral Genetics, Boulder, Colorado, U.S.A.;Institute of Psychiatry, London, U.K.;Western Psychiatric Institute, University of Pittsburgh, Pennsylvania, U.S.A.;Medical College of Virginia, Virginia Commonwealth University, Richmond, U.S.A. |
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| Abstract: | Structural equation models were applied to the maternal ratings of 265 MZ and 163 DZ male-male, 347 MZ and 160 DZ female-female, and 262 male-female twin pairs, aged 8-16 years, who participated in the Virginia Twin Study of Adolescent Behavioral Development (VTSABD). Substantial additive genetic influences and contrast effects were found for hyperactivity, and additive genetic and shared environmental effects or positive comparison effects (particularly for the girls) for oppositional/conduct disturbance. Bivariate model fitting showed that the covariation between hyperactivity and oppositional/conduct problems in both younger and older boys and girls is almost entirely attributable to genetic factors. However, whereas in the younger males and females the same set of genes explain all the variation in hyperactivity and conduct disturbance, in the older cohort at least some of the genetic effects are behavior- and gender-specific. |
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| Keywords: | Comorbidity genetics hyperactivity conduct disturbance |
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