糖化血红蛋白水平在糖尿病合并脑梗塞中的临床意义探讨

目的探讨糖化血红蛋白(GHb)水平在糖尿病合并脑梗塞中的临床意义。方法把GHb<6.5%作为划分值,将79例糖尿病合并急性脑梗塞患者分为GHb正常组(31例)和GHb异常组(48例),均给予常规治疗,分别在患者入院时和经治疗3周后进行神经功能缺损程度量化评分,然后比较两组的分数;并把两组的GHb值与入院分数和3周后分数作相关性分析。结果GHb异常组的入院分数高于GHb正常组,差异有统计学意义(P<0.05),提示病情较重;而且其3周后分数也高于GHb正常组,差异有统计学意义(P<0.01),提示病情恢复较差;两组的GHb值均与该两项评分呈正相关(P均<0.01)。结论了解糖尿病合并急性脑梗塞患者的GHb水平有助于监测病情、估计预后,对于在临床上及时采取积极的综合性治疗措施有较大的指导意义。

Clinical significance of the level of glycosylated hemoglobin in patients of diabetes mellitus with cerebral infarction

Objective To explore the clinical significance of the level of glycosylated hemoglobin(GHb) in patients of diabetes mellitus with cerebral infarction. Methods 79 cases of diabetes with acute cerebral infarction were divided into GHb normal group (31 cases) and GHb abnormal group (48 cases) by the value of GHb which was 6.5%. All of them were given conventional treatment. They were evaluated respectively at the beginning of hospitalization and three weeks after treatment by using nerval function defects score, and then the scores of these two groups were compared. The correlation between the value of GHb of these two groups and the scores was also analysed. Results The scores of GHb abnormal group were higher than that of GHb normal group significantly at the beginning of hospitalization (P<0.05). The scores of the former group were also higher than that of the latter group significantly at three weeks after (P<0.01). Both of these two results mean severe conditions,There existed positive correlation between the value of GHb and the scores in these two groups (P<0.01). Conclusion The level of GHb in patients of diabetes with acute cerebral infarction can help monitor the state of illness and estimate the prognosis. It is very significant in guiding timely comprehensive treatment.