11C]-dimethylamine as a labeling agent for PET biomarkers. |
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| Authors: | Orit Jacobson Eyal Mishani |
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| Affiliation: | Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University, P.O.B. 12000, Jerusalem 91120, Israel. |
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| Abstract: | The dimethylamine functional group is a common component of the chemical structure of numerous drugs. The most commonly used synthetic route for carbon-11 labeled radiopharmaceuticals which contain the dimethylamine group is via C-11 methylation of the monomethyl amine precursors. Here we describe the radiosynthesis of [11C]dimethylamine (1) and its application in the direct labeling of several positron emission tomography (PET) imaging agents by-passing the preparation of the monomethyl amine precursors. |
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