2种不输液途径对奥沙利铂化疗患者神经毒性的影响

目的探讨经外周静脉置人的中心静脉导管（PICC）与外周静脉留置针输入奥沙利铂对患者造成神经毒性的差异。方法将58例拟行奥沙利铂化疗方案的消化道恶性肿瘤患者分为PICC组（n=32）和外周组（n=29），PICC组经PICC输入奥沙利铂，外周组经外周静脉留置针输入奥沙利铂，对比观察2种给药途径引起周围神经毒性反应以及药物引起肢体疼痛情况。结果PICC组出现3例神经毒性反应，均为一级，无一例出现肢体疼痛;外周组18例出现神经毒性反应，其中一级10例，二级8例，有11例出现输注侧肢体局部疼痛。PICC组神经毒性发生率明显低于外周组，差异有统计学意义（P〈0．01）。结论经PICC输入奥沙利铂，神经毒性反应轻，可避免引起肢体疼痛，有利于提高患者化疗依从性。

Effects of two different ways of infusion on patients with neurotoxicity caused by oxaliplatin chemotherapy

Objective To explore the the different effects of two different ways of infusion on patients with neurotoxicity caused by oxaliplatin chemotherapy: peripheral inserted central catheter (PICC) vs peripheral central-vein indwelling needle (PCVIN). Methods A total of 58 gastrointestinal malignancy cases reicived oxaliplatin were divided into PICC group ( n = 32) and PCVIN group ( n = 29 ), incidence of toxicity and physical pain were compared. Results There were 3 cases with neurotoxicity( all at level 1 ) amd there were no cases with physical pain in PICC group, while there were 18 cases with neurotoxicity (10 cases at level 1 and 8 cases at level 2) and there were 11 cases with limb pain. The difference between groups was statistically significant (P＜0.01). Conclusions Oxaliplatin infusion through PICC can reduce neurotoxic reaction,decrease physical pain and improve patients' compliance with chemotherapy.