Objectively measured sedentary time and associations with insulin sensitivity: Importance of reallocating sedentary time to physical activity |
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| Affiliation: | 1. Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK;2. NIHR Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Unit, UK;3. Physical Activity Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia;4. NIHR Collaboration for Leadership in Applied Health Research and Care—East Midlands (NIHR CLAHRC—EM), UK;1. Department of Medicine, Division of General Internal Medicine, University of Minnesota, 717 Delaware St. SE Minneapolis, MN 55414, USA;2. Clinical and Translational Science Institute, University of Minnesota, 717 Delaware St. SE Minneapolis, MN 55414, USA;3. School of Public Health, Division of Biostatistics, University of Minnesota, 420 Delaware St SE Minneapolis, MN 55455, USA;4. Masonic Cancer Center, University of Minnesota, 420 Delaware St SE Minneapolis, MN 55455, USA;5. Center for Health Equity, University of Minnesota, 717 Delaware St. SE Minneapolis, MN 55414, USA;1. The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands;2. Department of Epidemiology, Rotterdam, The Netherlands;3. Department of Pediatrics, Erasmus University Medical Center, Rotterdam, The Netherlands;4. Department of Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands;5. Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands;1. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Biopôle 2, Route de la Corniche 10, 1010 Lausanne, Switzerland;2. Unit of Population Epidemiology, Division of primary care medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Switzerland;3. Department of Medicine, Internal Medicine, Lausanne University Hospital, rue du Bugnon 46, 1011 Lausanne, Switzerland;1. Department of Public Health Sciences, Queen''s University, Canada;2. Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Canada;3. Department of Oncology, Cumming School of Medicine, University of Calgary, Canada;4. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada;5. Surveillance and Cancer Registry, Cancer Care Ontario, Canada;6. Occupational Cancer Research Centre, Cancer Care Ontario, Canada;7. College of Public Health and Human Sciences, Oregon State University, USA;8. Canadian Cancer Society, Canada;9. Department of Health Sciences, Carleton University, Canada;10. Faculty of Health Sciences, McMaster University, Canada;1. Public Health, University Hospital, 80000 Amiens, France;2. College of Nursing, University of Kentucky, Lexington, KY, USA |
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| Abstract: | ObjectiveThe aim of this study is to quantify associations between objectively measured sedentary time and markers of insulin sensitivity by considering allocation into light-intensity physical activity or moderate- to vigorous-intensity physical activity (MVPA).MethodsParticipants with an increased risk of impaired glucose regulation (IGR) were recruited (Leicestershire, United Kingdom, 2010–2011). Sedentary, light-intensity physical activity and MVPA time were measured using accelerometers. Fasting and 2-hour post-challenge insulin and glucose were assessed; insulin sensitivity was calculated by HOMA-IS and Matsuda-ISI. Isotemporal substitution regression models were used. Data were analysed in 2014.Results508 participants were included (average age = 65 years, female = 34%). Reallocating 30 min of sedentary time into light-intensity physical activity was associated a 5% (95% CI 1, 9%; p = 0.024) difference in Matsuda-ISI after adjustment for measured confounding variables. Reallocation into MVPA was associated with a 15% (7, 25%; p < 0.001) difference in HOMA-IS and 18% (8, 28%; p < 0.001) difference in Matsuda-ISI. Results for light-intensity physical activity were modified by IGR status with stronger associations seen in those with IGR.ConclusionsReallocating sedentary time into light-intensity physical activity or MVPA was associated with differences in insulin sensitivity, with stronger and more consistent associations seen for MVPA. |
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