Dietary Patterns Are Differentially Associated with Atypical and Melancholic Subtypes of Depression |
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| Authors: | Auré lie M. Lasserre,Marie-Pierre F. Strippoli,Pedro Marques-Vidal,Lana J. Williams,Felice N. Jacka,Caroline L. Vandeleur,Peter Vollenweider,Martin Preisig |
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| Affiliation: | 1.Department of Psychiatry, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland; (M.-P.F.S.); (C.L.V.); (M.P.);2.Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland; (P.M.-V.); (P.V.);3.Barwon Health, IMPACT—The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong 3220, Australia; (L.J.W.); (F.N.J.) |
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| Abstract: | Diet has been associated with the risk of depression, whereas different subtypes of depression have been linked with different cardiovascular risk factors (CVRFs). In this study, our aims were to (1) identify dietary patterns with exploratory factor analysis, (2) assess cross-sectional associations between dietary patterns and depression subtypes, and (3) examine the potentially mediating effect of dietary patterns in the associations between CVRFs and depression subtypes. In the first follow-up of the population-based CoLaus|PsyCoLaus study (2009–2013, 3554 participants, 45.6% men, mean age 57.5 years), a food frequency questionnaire assessed dietary intake and a semi-structured interview allowed to characterize major depressive disorder into current or remitted atypical, melancholic, and unspecified subtypes. Three dietary patterns were identified: Western, Mediterranean, and Sweet-Dairy. Western diet was positively associated with current atypical depression, but negatively associated with current and remitted melancholic depression. Sweet-Dairy was positively associated with current melancholic depression. However, these dietary patterns did not mediate the associations between CVRFs and depression subtypes. Hence, although we could show that people with different subtypes of depression make different choices regarding their diet, it is unlikely that these differential dietary choices account for the well-established associations between depression subtypes and CVRFs. |
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| Keywords: | major depressive disorder depression subtypes atypical melancholic dietary patterns population-based study cross-sectional cardiovascular risk factors |
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