1039例隐源性肝炎患者AMA-M2抗体的筛查

目的在1039例隐源性肝炎患者中筛查AMA-M2抗体,对男性和女性的M2抗体滴度、M2抗体阳性患者和M2抗体阴性患者的免疫指标、PBC患者的临床表现等进行统计分析,以早期诊断PBC。方法采用ELISA法检测M2抗体滴度。结果在1039例隐源性肝炎患者中,81例(7.9%)M2抗体阳性,其中57例为女性,24例为男性,平均年龄53.0±14.8岁;在78例PBC患者中,乏力(74.4%,58/78)、黄疸(61.5%,48/78)和皮肤瘙痒(37.2%,29/78)多见;合并ANA阳性者39例(50.0%,39/78),合并抗-SSA/Ro抗体阳性14例(17.9%,14/78)。结论 AMAs的检测是诊断原发性胆汁性肝硬化的重要指标,检测M2抗体有助于早期诊断PBC。

Measurement of anti-mitochondria M2 antibodies in 1039 patients with cryptogenic hepatitis

Objective To investigate the presence of AMA-M2 antibodies in 1039 patients with cryptogenic hepatitis.Methods M2 antibodies were tested by ELISA.Results M2 antibodies were detected in 81(7.9%)of the 1039 patients;Of the 81 cases,57 were female and 24 were male,and the mean age was 53.0 ± 14.8 year old,and 78 patients were diagnosed as PBC;The most common symptoms were fatigue(74.4%,58/78),jaundice(61.5%,48/78)and skin itching(37.2%,29/78);Besides,39(50.0%) patients were with ANA positive,and 14(18.0%) with anti-SSA/Ro positive.Conclusion On the diagnosis of the disease,the detection of serum antimitochondrial autoantibodies(AMA) is an important indicator.The detection of AMA-M2 is important for early diagnosis of patients with PBC.