声触诊组织量化技术测量脾脏剪切波速度评估慢性乙型肝炎纤维化程度的初步研究

目的利用声触诊组织量化技术测量脾脏剪切波速度,探讨脾脏剪切波速度变化对诊断慢性乙型肝炎患者肝纤维化程度的价值。方法利用声触诊组织量化技术对51例慢性乙型肝炎患者、39例肝硬化患者和32例健康人脾脏进行超声检查,测得感兴趣区脾脏剪切波速度,比较三组受检者脾脏剪切波速度值的差异。结果健康人、慢性乙型肝炎和肝硬化患者脾脏剪切波速度值分别为2.0±0.2、2.3±0.4和3.1±0.5,三者间具有显著性差异(P=0.000),且随着肝纤维化程度的加重,脾脏剪切波速度值明显增高。肝硬化患者脾脏剪切波速度值明显高于慢性乙型肝炎患者,后者又高于健康人。结论声触诊组织量化技术检测脾脏剪切波速度可用于无创评价脾脏硬度信息,并由此推测肝纤维化程度。

The preliminary study of spleen shear wave velocity measured by virtual touch tissue quantification technique in assessment of liver fibrosis stage in patients with chronic hepatitis B and liver cirrhosis

Objective The virtual touch tissue quantification(VTQ) technique was used to measure spleen shear wave velocity(SWV) for the evaluation of liver fibrosis in patients with chronic hepatitis B.Method 51 patients with chronic hepatitis B,39 with liver cirrhosis and 32 healthy persons were included and their values of SWV in regions of interest of spleen were performed by VTQ technique.Result The values of SWV were 2.0±0.2,2.3±0.4 and 3.1±0.5,respectively in healthy persons,patients with hepatitis B and liver cirrhosis,and they were significantly different among the three groups(P=0.000);The SWV values increased as the severity of liver fibrosis progressed.Conclusion The VTQ technique could quantitatively reflect the SWV values and noninvasively evaluate the spleen stiffness,which might be an alternative assessment of liver fibrosis in patients with hepatitis B.