宫颈鳞癌患者放疗前行腹腔镜卵巢移位术30例临床效果分析

目的:探讨宫颈鳞癌患者在放疗前行腹腔镜下卵巢移位术对卵巢内分泌功能的影响。方法:研究组(n=30):选择40岁以下ⅡB～ⅢA期宫颈鳞癌患者,在放疗前行腹腔镜下卵巢移位术;对照组(n=20)为同期确诊的40岁以下ⅡB～ⅢA期宫颈鳞癌患者,未接受卵巢移位术直接放疗者。两组分别于放疗前、放疗后12月测患者卵泡期血清E2、FSH和LH水平,行围绝经期综合征量表(Kupperma)评分,观察其围绝经期症状出现情况。结果:研究组和对照组放疗前患者的E2、FSH和LH水平及均Kupperman评分比较,差异无统计学意义(P>0.05);研究组放疗后12个月16例出现卵巢功能下降,对照组则2例出现卵巢功能下降,18例出现卵巢功能丧失;两组间激素水平及Kupperman评分比较,差异有统计学意义(P<0.05)。结论:年轻晚期宫颈鳞癌患者放疗前行腹腔镜下卵巢移位术,可使卵巢功能得到一定的保护。

Clinical Analysis of 30 Cases with Laparoscopic Ovarian Transposition before Radiotherapy in Cervical Squamous Carcinoma

Objective:To investigate the effects of laparoscopic ovarian transposition on ovarian function in cervical squamous carcinoma before radiotherapy.Methods:Thirty patients younger than forty years old with ⅡB～ⅢA cervical carcinoma treated with laparoscopic ovarian transposition before radiotherapy were regarded as study group.Twenty patients younger than forty years old without laparoscopic ovarian transposition before radiotherapy were regarded as control group.The levels of blood E2,FSH,LH in follicular phase were detected respectively before radiations and 12 months after radiations in two groups.The Kupperman standard(1995) was used to investigate the climacteric syndrome.Results:The levels of blood E2,FSH,LH and average Kupperman scores before radiation in two groups were in the normal ranges.There was no statistical difference between two groups(P>0.05).Declined ovarian function was happened in 16 cases 12 months after radiation in study group.There were 2 cases with declined ovarian function and 18 cases with ovarian dysfunction in control group.There were statistical difference about hormonal levels and Kupperman scores in two groups(P<0.05).Conclusions:Laparoscopic ovarian transposition in patients with late cervical carcinoma before radiotherapy can reserve ovarian function.