瞬时受体电位阳离子通道蛋白6在肾小球足细胞损伤中的作用

瞬时受体电位阳离子通道蛋白6(TRPC6)是新近发现的肾小球足细胞分子,定位于足细胞裂孔隔膜,与nephrin、podocin和CD2AP存在共定位分布,共同参与信号转导,并维持足细胞正常的结构和功能。TRPC6基因突变可以导致常染色体显性家族性局灶节段性肾小球硬化,患者表现为大量蛋白尿和足细胞损伤,体外试验也表明其高表达可通过增加钙离子内流损伤足细胞,说明TRPC6与蛋白尿的发生、发展密切相关。现将阐明TRPC6在足细胞损伤中的作用,有望为肾脏病的诊断和治疗提供新的靶点。

Role of Transient Receptor Potential Cation Channel 6 in Podocyte Injury

Recent studies have shown that transient receptor potential cation channel 6(TRPC6) expressed in podocytes,and located in slit diaphragm,it colocalized with nephrin,podocin and CD2AP,participating in signal transduction and maintaining podocytes normal construction and function.Mutations in TRPC6 cause autosomal dominant familial focal segmental glomerulosclerosis which is characterized by grade proteinuria and podocyte injury.In vitro studies,it also indicates that overexpression of TRPC6 leads to podocyte dysfunction,maybe through elevating calcium influx,suggesting that TRPC6 associates with the onset and development of proteinuria.This article will describe the role of TRPC6 in podocyte injury,maybe provide us the new targets for diagnosing and theraping renal disorders in the future.