子宫内膜癌雄激素受体表达及临床意义

目的:探讨子宫内膜癌组织中的雄激素受体(AR)的表达及其与临床病理特征和雌激素受体(ER)、孕激素受体(PR)表达的关系。方法:应用免疫组织化学SP法检测41例正常子宫内膜、18例不典型增生及116例子宫内膜癌组织中AR、ER、PR的表达。结果:①子宫内膜细胞普遍存在AR的表达,在正常子宫内膜、不典型增生子宫内膜、子宫内膜癌组织中阳性表达率逐渐增高,但差异无统计学意义(P=0.424)。②AR在子宫内膜癌中的表达随患者FIGO分期、组织病理分级的升高而下降(P=0.011;P=0.047),而与患者发病年龄、是否绝经、组织学类型、淋巴结有无转移、肌层有无浸润无明显关系(P>0.05)。③AR的表达与ER、PR的表达呈正相关(r=0.293,P=0.001;r=0.275,P=0.003)。结论:AR在子宫内膜癌的发生、发展中可能起重要作用,AR阳性表达者的生物学行为较好。

Expression and Clinical Significance of Androgen Receptor in Endometrial Carcinoma

Objective:To investigate the significance of androgen receptor(AR) expression and its correlation with estrogen receptor and progesterone receptor(ER/PR) and clinicopathological characteristics in endometrial carcinoma.Methods:The expressions of AR,ER and PR were detected by immunohistochemistry SP method in 41 cases of normal endometrium,18 cases of atypical hyperplasia and 116 cases of endometrial cancer.Results:There was general expression of AR in endometrial carcinoma.AR expression increased from normal endometrial to atypical hyperplasia and endometrial carcinoma,but there were no significant differences among the three groups(P=0.424).The expression rate of AR was decreased with increasing FIGO stage and histological grade(P=0.011;P=0.047).There were no statistical differences between AR expression and age,menopause,histological type,myometrial invasion,and lymph nodes metastasis(P>0.05).There was positive correlation between expression of AR,ER and PR(r=0.293,P=0.001;r=0.275,P=0.003).Conclusions:AR may play an important role in the development and progression of endometrial carcinoma.Positive expression of AR implies better biological behavior of endometrial carcinoma.