当飞利肝宁联合卵磷脂治疗非酒精性脂肪性肝炎临床观察

目的观察当飞利肝宁联合卵磷脂对非酒精性脂肪性肝炎(NASH)患者的临床疗效。方法 116例NASH患者被随机分成3组。联合治疗组(45例)给予当飞利肝宁和卵磷脂片,当飞利肝宁组(38例)和卵磷脂组(33例)分别给予当飞利肝宁和卵磷脂片口服治疗,疗程均为3个月。观察患者治疗前后主要症状、肝功能、血脂及B超检查脂肪肝程度的变化。结果联合治疗组在纳差、乏力、肝区不适改善方面优于卵磷脂组(x2=3.94、x2=10.63、x2=8.54,P<0.05或P<0.01),当飞利肝宁组乏力改善也优于卵磷脂组(x2=3.97,P<0.05);联合治疗组和当飞利肝宁组AST、ALT较卵磷脂组降低(P<0.05,P<0.01),联合治疗组AST、ALT、TG、TC降低也优于当飞利肝宁组(P<0.05或P<0.01);治疗后联合治疗组和卵磷脂组B超发现脂肪肝程度的变化均有显著改善(P<0.01或P<0.05),联合治疗组与当飞利肝宁组减轻更明显(P<0.01);少数患者服用当飞利肝宁后有腹胀、恶心、厌食等胃肠道反应。结论当飞利肝宁联合卵磷脂治疗NASH有较好的疗效和安全性。

A clinical observation of Dangfei Liganning combined with lecithin for treating patients with non-alcoholic steatohepatitis

Objective To observe the clinical efficacy of Dangfei Liganning combined with lecithin for treating patients with non-alcoholic steatohepatitis(NASH).Methods 116 patients with NASH were randomly divided into three groups.The combination therapy group(n=45)was treated with Dangfei Liganning and lecithin tablets,and the Dangfei Liganning group(n=38)and lecithin group(n=33)were treated with Dangfei Liganning and lecithin tablets orally,respectively.The regimen lasted for three months.Before and after treatment,clinical data including main symptoms,hepatic function parameters,blood cholesterol and fatty liver image under B ultrasound in the three groups were monitored respectively.Results The rates of symptoms alleviation such as fatigue,anorexia,abdominal discomfort in the combination therapy group were higher than in the lecithin group(x2=3.94,x2=10.63,x2=8.54,P<0.05 or P<0.01).Fatigue improvement was better in the Dangfei Liganning group than in the lecithin group(x2=3.97 or P<0.05);The levels of AST and ALT were declined obviously in the combination therapy group and Dangfei Liganning group than in the lecithin group after treatment(P<0.05 or P<0.01).AST,ALT,TG,TC were also lower in the combination therapy group than in the Dangfei Liganning group(P<0.05 or P<0.01);Fatty liver under B ultrasound in the combination therapy group and lecithin group were obviously improved after treatment(P<0.05 or P<0.01);Some patients had abdominal distension,nausea,anorexia and other gastrointestinal reactions after taking Dangfei Liganning.Conclusion Dangfei Liganning combined with lecithin has good clinical efficacy and security for the treatment of patients with NASH.