氟伏沙明治疗伴有焦虑的抑郁症对照研究

目的：比较氟伏沙明与氟西汀治疗伴有焦虑的抑郁症疗效和不良反应。方法：71例伴有焦虑的抑郁症患者随机分为氟伏沙明组36例和氟西汀组35例,分别给予氟伏沙明和氟西汀治疗。疗程8周。采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、治疗中出现的症状量表（TESS）评定疗效和不良反应。结果：两组HAMD和HAMA评分治疗后均较治疗前显著下降（P均〈0.01）;以氟伏沙明组在治疗1周起即显著下降（P〈0.01）,而氟西汀组在治疗2周起显著下降（P〈0.01）;两组间比较差异有显著性（P〈0.05或P〈0.01）。两组不良反应相仿。结论：氟伏沙明与氟西汀治疗伴有焦虑的抑郁症均安全有效,但氟伏沙明起效更快。

Fluvoxamine in treating depressive disorder with anxiety

Objective：To compare the clinical effects and adverse reactions of fluvoxamine and fluoxetine in treatment of depression with anxiety. Method：71 patients with depression with anxiety were randomized into either fluvoxamine group （n=36） or fluoxetine group （n=35） for 8 weeks. Hamilton depressive scale （HAMD）,Hamilton anxiety scale （HAMA） and treatment emergent symptom scale （TESS） were used to evaluate the efficacy and side effects. Results：The HAMD and HAMA score of both groups decreased significantly compared with those before treatment （all P0.01）.The significant decrease was showed in fluvoxamine group after 1week treatment but in fluoxetine group after 2 weeks treatment（P0.01）.There were significant differences between the two groups（P0.05 or P0.01）.The overall adverse reactions in both groups showed no significant difference. Conclusion：Fluvoxamine and fluoxetine are equally safe and effective drug in treatment of depression with anxiety,but fluvoxamine may act more rapidly than fluoxetine.