非淋病性尿道炎患者解脲脲原体耐药性分析

目的：通过调查非淋病性尿道炎患者解脲脲原体（Uu）感染现状及耐药性,为临床医师合理使用抗菌药物提供实验依据。方法：采用法国生物梅里埃公司Mycoplasma IST2支原体试剂盒对1897例非淋病性尿道炎患者进行支原体培养和药敏试验。结果：Uu阳性检出率为43.2%（819/1897）。Uu对喹诺酮类抗菌药物环丙沙星、氧氟沙星敏感率最低,分别为14.8%、24.7%;对原始霉素、强力霉素、交沙霉素敏感率较高,分别为100%、100%、97.4%;对红霉素、四环素敏感率分别为62.5%、91.4%;对阿奇霉素、克拉霉素敏感率均为75.9%。结论：Uu为非淋病性尿道炎的重要病原体,必须加强耐药性检测,以有效控制Uu感染。

Antimicrobial resistance of ureaplasma urealyticum from patients with non-gonococcal urethritis

Objective：To investigate the infection status and antimicrobial resistance of Ureaplasma urealyticum（Uu）from patients with non-gonococcal urethritis in our hospital and provide the experimental evidence for the clinically reasonable use of antibiotics.Method：The Uu cultivation and drug susceptibility tests were performed for 1897patients with non-gonococcal urethritis by bioMérieux Mycoplasma IST2kit.Result：The total positive detection rate of Uu was 43.2%（819/1897）.The rate of drug sensitivity to quinolones,such as ciprofloxacin（14.8%） and ofloxacin（24.7%）,was the lowest.The rates of drug sensitivity to pristinamycin（100.0%）,doxycycline（100.0%）and Josamycin（97.4%）were higher.Those to erythromycin and tetracycline were 62.5% and 91.4%,respectively.Both of azithromycin and clarithromycin were 75.9%.Conclusion：Uu was the main pathogene causing non-gonococcal urethritis.Monitoring of antimicrobial resistance of Uu should be strengthened in order to control effectively the infection with Uu.