Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression |
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| Authors: | Dubois L Dresselaers T Landuyt W Paesmans K Mengesha A Wouters B G Van Hecke P Theys J Lambin P |
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| Affiliation: | Department of Radiation Oncology (Maastro Lab), GROW Research Institute, University of Maastricht, UNS 50/23, 6200 MD, Maastricht, The Netherlands. |
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| Abstract: | The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo (19)F-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring. |
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| Keywords: | 19F-MRS Salmonella typhimurium gene therapy cytosine deaminase xenograft human tumour |
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