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Risk factors of vertebral fractures in women with systemic lupus erythematosus |
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| Authors: | Claudia Mendoza-Pinto Mario García-Carrasco Hilda Sandoval-Cruz Margarita Muñoz-Guarneros Ricardo O Escárcega Mario Jiménez-Hernández Pamela Munguía-Realpozo Manuel Sandoval-Cruz Margarita Delezé-Hinojosa Aurelio López-Colombo Ricard Cervera |
| Institution: | 1. Systemic Autoimmune Diseases Research Unit, HGR #36, CMN Manuel Avila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico 2. Rheumatology and Immunology Department, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico 3. Radiology Unit, HGR #36, CMN Manuel Avila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico 4. State Research and Posgrado, Medicine School Benemérita Universidad Autónoma de Puebla, Puebla, Mexico 5. Internal Medicine, Temple University Hospital, Philadelphia, PA, USA 6. Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic, Villarroel 170, 08036, Barcelona, Catalonia, Spain 7. Internal Medicine Unit, HGR36, CMN Manuel Avila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico 8. Osteoporosis Clinic, Hospital Angeles, Puebla, Mexico 9. State Research Departament, Instituto Mexicano del Seguro Social, Puebla, Mexico |
| Abstract: | The aim of the current study was to analyze the role of traditional and systemic lupus erythematosus (SLE)-related risk factors in the development of vertebral fractures. A cross-sectional study was performed in women with SLE attending a single center. A vertebral fracture was defined as a reduction of at least 20% of vertebral body height. Two hundred ten patients were studied, with median age of 43 years and median disease duration of 72 months. Osteopenia was present in 50.3% of patients and osteoporosis in 17.4%. At least one vertebral fracture was detected in 26.1%. Patients with vertebral fractures had a higher mean age (50 ± 14 vs. 41 ± 13.2 years, p = 0.001), disease damage (57.1% vs. 34.4%, p = 0.001), lower bone mineral density (BMD) at the total hip (0.902 ± 0.160 vs. 982 ± 0.137 g/cm2, p = 0.002), and postmenopausal status (61.9% vs. 45.3%, p = 0.048). Stepwise logistic regression analysis revealed that only age (p = 0.001) and low BMD at the total hip (p = 0.007) remained as significant factors for the presence of vertebral fracture. The high prevalence of vertebral fractures in the relatively young population implies that more attention must be paid to detect and treat vertebral fractures. |
| Keywords: | Risk factors Systemic lupus erythematosus Vertebral fractures |
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