颈动脉粥样硬化中医证型与相关因素的研究

目的 探讨颈动脉粥样硬化中医证型分类方法及其与危险因素、实验室指标的相关性.方法 制定颈动脉粥样硬化临床观察表,采集病史及中医四诊资料,同步检测颈动脉内膜-中膜厚度、血压、血脂、空腹血糖、空腹胰岛素等,采用因子分析、SOM神经网络、CMH-2检验等进行统计学分析,探讨颈动脉粥样硬化中医证型分类方法及其与危险因素、实验室指标的关系.结果 ①得到颈动脉粥样硬化6大基本证型.②随年龄增长颈动脉粥样硬化患病率有上升趋势.③单一家族史中以高血压病最多见,合并家族史中以高血压病合并脑血管意外最多见.单一基础疾病中以高血压病最多见,合并基础疾病中以高血压病合并高脂血症最多见.④颈动脉粥样硬化中医证型与斑块面积、血脂、胰岛素敏感指数等均不存在显著差异.结论 ①颈动脉粥样硬化6大基本证型是肾精亏虚、心气(阳)虚兼精血亏虚、精亏痰浊兼脾气虚、肾精亏虚兼心气血虚、肾精亏虚兼阴血亏虚、精亏痰浊兼心脾两虚.其中,肾精亏虚是基本证型,以虚实夹杂为多见.②增龄、高血压是动脉粥样硬化的重要危险因素.③在本研究中,颈动脉粥样硬化中医证型与斑块面积、血脂、胰岛素敏感指数等没有显著相关性.

Carotid Atherosclerosis Syndromes with Risk Factors and Laboratory Parameters Analysis

Objective Investigation over classification of Atherosclerosis syndromes in Traditional Chinese Medicine,as well as the correlation between Atherosclerosis and Western Medicine indexes.Method By means of rolling out clinical observation table of carotid atherosclerosis,collecting history and Traditional Chinese Medical information,Carotid Intima-Media Thickness,Synchronous Blood Pressure,Blood Lipids,Fasting Glucose,Fasting Insulin and so on,and using Factor Analysis,SOM Neural Network,CMH-2Test,analyze the data statistically in order to have a further study and investigation over Classification of Atherosclerosis Syndromes in Traditional Chinese Medicine,and its correlation with risk factors and laboratory parameters.Results(1)Six basic syndromes of Carotid Atherosclerosis are concluded.(2) With the increase of the age,prevalence rates of carotid atherosclerosis tend to increase.(3) Hypertension in single family history are most prevalent,accident of hypertension with cerebral vascular in merged family history are most prevalent.In Single-base diseases hypertension is the most common,in primary diseases hypertension combined with hyperlipidemia is the most common.(4) There is no significant difference between Carotid Atherosclerosis TCM and Carotid Intima-Media Thickness,Blood Lipids,Insulin Sensitivity Index and so on(P>0.05).Conclusions(1) Carotid Atherosclerosis’s six basic syndromes are Kidney essence deficiency,Heart qi(yang) and deficiency of kidney essence virtual,deficiency of kidney essence,phlegm and Spleen deficiency,deficiency of kidney essence and congestive,blood deficiency,deficiency of kidney essence and deficiency of yin essence and blood,deficiency of kidney essence,Qi and blood and Phlegm.Among them,the kidney essence deficiency is the basic card types.Virtual evidence mixed with actual are commonly found.(2) Age,arterial hypertension are risk factors for atherosclerosis.(3)The finding in our research there is no correlation between Carotid Atherosclerosis TCM and Carotid Intima-Media Thickness,Blood Lipids,Insulin Sensitivity Index and so on.