辛伐他汀治疗对动脉粥样硬化性急性脑梗死患者血ROCK2活性的影响及其与炎症因子的相关性

目的 探讨辛伐他汀对动脉粥样硬化性急性脑梗死患者血浆炎症因子如肿瘤坏死因子-α(TNF-α),C-反应蛋白(CRP),Rho关联含卷曲螺旋蛋白激酶(ROCK2)活性的影响及炎症因子水平与ROCK2的相关性,初步阐明辛伐他汀对急性脑梗死患者疗效的作用机制.方法 根据CT和(或)MRI诊断急性脑梗死患者,采用随机对照的方法,将符合诊断标准的发病48h内的80例急性脑梗死患者随机分为治疗组和对照组.对照组患者常规给予抗凝、抗血小板聚集、血压控制等基础治疗,而治疗组则在基础治疗的基础上给予口服辛伐他汀40mg治疗.在治疗前和治疗后测定美国国立卫生研究院卒中量表评分(NIHSS),取血测炎症因子TNF-α,CRP和ROCK2水平,并进行相关性分析,观察周期为14d.结果 与对照组患者比较,治疗组患者血炎症因子(TNF-α,CRP)和ROCK2水平显著降低,NIHSS评分显著降低,P＜0.05.结论 急性脑梗死早期应用辛伐他汀治疗可显著改善NIHSS评分并降低机体的炎症水平,可能与抑制ROCK2的活性有关.

The ROCK2 Activities Variation in Atherosclerosis Related Acute Cerebral Infarction Treated with Simvastatin and the Correlation with the Changes of Inflammation Factors

Objective Explore the ROCK2 activities variation in Atherosclerosis related acute cerebral infarction treated with Simvastatin and the correlation with the changes of inflammation factors,Preliminary to clarify the mechanism of action of simvastatin on acute cerebral infarction.Methods Diagnosis patients with acute cerebral infarction based on CT and(or)MRI.80 patients were diagnosed with acute cerebral infarction were divided into two groups randomly,the control group and the simvastatin group.The patients in control group were given the basic treatment,such as blood pressure control,anti blood plate aggregation,anti coagulant.In treatment group,the patients were given the basic treatment and the simvastatin(40mg,Qd).Before and after treatment,the NIHSS was evaluation and the TNF-α,CRP and ROCK2 in the serum were detected by ELISA kit.The correlation of the CRP and ROCK2,TNF-αand ROCK2 were analysis.The observation period was 14 days. Results Compared with the control group,the serum levels of TNF-α,CRP and ROCK2 were lower,P<0.05;the NIHSS score were lower in the simvastatin treatment group,P<0.05 versus control.Conclusion Atherosclerosis related acute cerebral infarction treated with Simvastatin may improves the NIHSS score and lower the inflammation factors,these may be associated with the inhibition of the ROCK2 activities.