Vergleich der hämodynamischen Wirkungen vonD-Sotalol undD,L-Sotalol

Summary The hemodynamic effects of the class III drugD-sotalol and of the beta adrenergic receptor antagonistD,L-sotalol were compared in 16 rats (2 mg/kg i.v.). A group with NaCl-infusion served as control (n=10). Besides measurements in the intact circulation isovolumic registrations were performed to examine the left ventricular myocardial function without interferences.D,L-sotalol significantly reduced the dp/dt_max (61%) and the peak isovolumic left ventricular pressure (64%). It lowered the heart rate by 13% and slightly increased the mean aortic pressure to 107% (p<0.05).D-sotalol, in contrast, caused only a very transient reduction of the dp/dt_max and was comparable to the controls already 5 min after injection. The results demonstrate, that theD-enantiomer is largely avoid of the hemodynamic effects of the racemicD,L-sotalol after intravenous injection.

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Abkürzungen LVP systolischer linksventrikulärer Druck - EDP enddiastolischer linksventrikulärer Druck - AoPm mittlerer Aortendruck - peak LVSP maximaler isovolumetrischer linksventrikulärer Druck - peak dp/dtmax höchstes dp/dtmax bei isovolumetrischer MessungMit Unterstützung der DFG