Distribution of neuropeptide Y in the lower brainstem: an immunohistochemical analysis |
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| Authors: | M. Yamazoe S. Shiosaka P.C. Emson M. Tohyama |
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| Affiliation: | 1. Department of Neuroanatomy, Institute of Higher Nervous Activity, Osaka University Medical School, 4-3-57 Nakanoshima Kitaku, Osaka 530 Japan;2. Neurochemical Pharmacology Unit, MRC, Cambridge U.K.;1. Department of Orthopaedic Surgery, MedStar Union Memorial Hospital, Baltimore, MD;2. Engineer, Department of Orthopaedic Surgery, MedStar Union Memorial Hospital, Baltimore, MD;1. Department of Archaeology, Faculty of Humanities, University of Oulu, PO Box 5000, FI-90014 Oulu, Finland;2. Cancer Research and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, PO Box 5000, FI-90014 Oulu, Finland;3. Medical Research Center Oulu, Faculty of Medicine, University of Oulu and Oulu University Hospital, PO Box 5000, FI-90014 Oulu, Finland;4. Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, PO Box 5000, FI-90014 Oulu, Finland;5. Center for Life Course Health Research, Faculty of Medicine, University of Oulu, PO Box 5000, FI-90014 Oulu, Finland;6. Finnish Institute of Occupational Health, Aapistie 1, FI-90220 Oulu, Finland |
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| Abstract: | The distribution of neuropeptide Y (NPY)-like immunoreactive (NPYI) structures in the rat lower brainstem was examined by means of indirect immunofluorescence or peroxidase-antiperoxidase methods. In addition to the well known immunoreactive NPYI containing cell groups, the present study demonstrated a much wider distribution of immunoreactive NPYI cells in the lower brainstem, i.e. substantia nigra pars lateralis, interpeduncular nucleus, inferior colliculus, nucleus cuneiformis, dorsal tegmental nucleus of Gudden, nucleus laterodorsalis tegmenti, nucleus vestibularis medialis, nucleus vestibularis inferioris, in the fasciculus longitudinalis medialis and nucleus parvocellularis compacta. We also demonstrated an extensive network of NPYI fibers in various areas of the lower brainstem including the auditory system, viscerosensory system, visceromotor system, raphe nuclei, reticular formation, parabrachial area, locus coeruleus and interpeduncular nucleus, etc. The possible importance of NPY is briefly discussed. |
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| Keywords: | neuropeptide Y localization immunohistochemistry lower brain stem rat |
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