The effects of drugs on Onchocerca volvulus. 4. Trials of melarsonyl potassium

The effects of the arsenical drug melarsonyl potassium on Onchocerca volvulus were investigated in patients in Cameroon infected with the Cameroon forest and Sudan savanna strains of the parasite. Two intramuscular dosage schedules were tested: the first comprised 4 consecutive daily doses of 200 mg repeated once after a 10-14 day interval, i.e., 2 (4×200 mg). The second was a single dose schedule at 7.1 mg/kg—10 mg/kg, with a maximum of 500 mg.