盐酸氟桂利嗪辅助治疗难治性癫痫的临床疗效观察

目的：探讨盐酸氟桂利嗪辅助治疗难治性癫痫的临床疗效及安全性。方法：依据随机双盲对照将90例难治性癫痫患者随机分为观察组和对照组各45例。对照组给予传统抗癫痫药物治疗，观察组在对照组治疗的基础上加用盐酸氟桂利嗪（FNZ）。治疗3个月后，进行两组疗效比较。结果：观察组治疗总有效率为85．3％高于对照组的66．7％，差异有统计学意义（P〈0．05）。两组1个月治疗及3个月疗程结束后发作频率与基线期发作频率比较明显减少，差异有统计学意义（P均〈0．01）。观察组在3个月疗程结束后发作频率较对照组明显减少，差异有统计学意义（P〈0．01）。两组治疗后脑电图也有改善，但两组治疗后比较及治疗前后比较差异无统计学意义（P〉0．05）。观察组未见明显不良反应。结论：盐酸氟桂利嗪作为难治性癫痫的添加治疗有效且安全性好。

Clinical Efficacy of Flunarizine Hydrochloride Adjuvant Treatment of Refractory Epilepsy

Objective： To investigate the clinical efficacy and safety of flunarizine hydrochloride as adjunctive therapy in patients with refractory epilepsy. Method： Based on a randomized double-blind, 90 patients with refractory epilepsy patients were randomly divided into observation group and the control group, 45 cases in each group. The control group was given traditional antiepileptie drug treatment, the observation group, the addition of hydrochloric acid in the treatment of the control group on the basis of flunarizine （ FNZ ）. Compared treatment efficacy of two groups after 3 months. Result： In the observation group, the total effective rate was 85.3% ,which was higher than that of control group （66.7%） , the difference was sta- tistically significant （ P 〈0. 05 ）. The seizure frequency and baseline seizure frequency significantly de-creased after one month and 3 months treatment in two groups, the difference was statistically significant （ P 〈 0.01 ）. 3 months after treatment, seizure frequency in observation group was decreased significantly, the difference was statistically significant （ P 〈 0.01 ）. After treatment, EEG also improved in two groups, but compared before and after treatment, there was no statistically significant difference （ P 〉 0. 05）. There was no obvious adverse reaction in the observation group . Conclusion： Flunarizine hydroehloride as refractory epilepsy add-on therapy is effective and safe.