肿瘤坏死因子受体相关因子6与凋亡关系的研究进展

目的总结肿瘤坏死因子受体相关因子6（TRAF6）与凋亡的关系。方法通过检索国内外相关文献,总结TRAF6在调节凋亡信号通路中的角色及其在相关疾病发生和发展过程中的作用。结果 TRAF6通过参与多条信号传导通路调节凋亡,在不同的组织器官及不同的刺激下对调节凋亡发挥不同的作用。TRAF6通过抑制凋亡促进肿瘤发生,而在神经系统和炎症相关疾病中则发挥促凋亡或促存活作用。结论 TRAF6通过调节凋亡,在肿瘤、神经系统及炎症相关疾病的发生和发展中均扮演了重要的角色。

The Progress of Research on The Relationship Between TRAF6 and Apoptosis

Objective To summarize the relationship between tumor necrosis factor receptor-associated factor 6（TRAF6）and apoptosis.Methods Domestic and international researches on progress of TRAF6 and apoptotic signaling pathway,especially focused on the functional features of TRAF6 in different system diseases were searched and reviewed.Results TRAF6 took part in several signaling pathways,which had been implicated in regulating apoptosis,and its roles differed in different system diseases and in different conditions.TRAF6 promoted tumorigenesis by inhibiting apoptosis,while it played a proapoptotic or prosurvival role in nervous system and inflammatory diseases.Conclusion TRAF6 plays an important role in apoptosis and involves in the development of tumor,nervous system disease,and inflammatory diseases.