| Abstract: | Lymphocytotoxic sera have been produced in forty-seven cattle following skin grafting or lymphocyte immunization between dam-offspring pairs. From these sera seventy antilymphocyte reagents have been produced. Seven of the sera were operationally monospecific without absorption, thirty-seven others were made operationally monospecific and twenty-six partially purified by absorption with lymphocytes. Thirty-five of these sera were used in France and an additional thirty-five were used in Scotland. The inheritance of the antigenic factors detected by these sera has been studied in 480 cattle families and the evidence is consistent with the hypothesis that at least seventeen of the factors are inherited in a simple Mendelian fashion. Fourteen of these factors show evidence of linkage with at least one other factor and are likely to be controlled by a limited number of closely linked loci. It is suggested that these loci should be identified as the BLA region. |
