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| Effect of AVP on brain edema following traumatic brain injury | |
| 作者姓名： | 徐妙 苏伟 黄卫东 陆远强 徐秋萍 陈兆军 |
| 作者单位： | Department of Critical Care Medicine Sir Run Run Shaw Hospital Medical College of Zhejiang University Hangzhou 310016 China，Department of Critical Care Medicine Sir Run Run Shaw Hospital Medical College of Zhejiang University Hangzhou 310016 China，Emergency Department First Affiliated Hospital Medical College of Zhejiang University Hangzhou 310009 China，Department of Critical Care Medicine Sir Run Run Shaw Hospital Medical College of Zhejiang University Hangzhou 310016 China，Department of Critical Care Medicine Sir Run Run Shaw Hospital Medical College of Zhejiang University Hangzhou 310016 China，Radio Immunology Center Hangzhou 310015 China |
| 基金项目： | This study was supported by the Science and Technology Department of Zhejiang Province （ No. 2004C33048 ） and the Science and Technology Bureau of Hangzhou City （No. 200433368 ） |
| 摘 要： | Objective: To evaluate plasma arginine vasopressin (AVP) level in patients with traumatic brain injury and investigate the role of AVP in the process of brain edema. Methods: A total of 30 patients with traumatic brain injury were involved in our study. They were divided into two groups by Glasgow Coma Scale: severe traumatic brain injury group (STBI, GCS≤8) and moderate traumatic brain injury group ( MTBI, GCS >8). Samples of venous blood were collected in the morning at rest from 15 healthy volunteers (control group) and within 24 h after traumatic brain injury from these patients for AVP determinations by radioimmunoassay. The severity and duration of the brain edema were estimated by head CT scan. Results: plasma AVP levels (ng/L) were (mean±SD): control, 3. 06±1. 49; MTBI, 38. 12±7. 25; and STBI, 66. 61±17. 10. The plasma level of AVP was significantly increased within 24 h after traumatic brain injury and followed by the reduction of GCS, suggesting the deterioration of cerebral injury (P<0. 01). And the AVP level was correlated with the severity (STBI r =0.919, P < 0.01; MTBI r = 0.724, P < 0.01) and the duration of brain edema (STBI r = 0. 790, P < 0. 01; MTBI r = 0. 712, P<0.01). Conclusions: The plasma AVP level is closely associated with the severity of traumatic brain injury. AVP may play an important role in pathogenesis of brain edema after traumatic brain injury. |
| 关 键 词： | 脑水肿 创伤 精氨酸抗利尿激素 脑伤 血脑屏障 |
| 收稿时间： | 2006-09-12 |
Effect of AVP on brain edema following traumatic brain injury |
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| XU Miao,SU Wei,HUANG Wei-dong,LU Yuan-qiang,XU Qiu-ping,CHEN Zhao-jun.Effect of AVP on brain edema following traumatic brain injury[J].Chinese Journal of Traumatology(English Edition),2007,10(2):90-93. | |
| Authors: | XU Miao SU Wei HUANG Wei-dong LU Yuan-qiang XU Qiu-ping CHEN Zhao-jun |
| Institution: | 1. Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou 310016, China 2. Emergency Department, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China 3. Radio Immunology Center,Hangzhou 310015,China |
| Abstract: | OBJECTIVE: To evaluate plasma arginine vasopressin (AVP) level in patients with traumatic brain injury and investigate the role of AVP in the process of brain edema. METHODS: A total of 30 patients with traumatic brain injury were involved in our study. They were divided into two groups by Glasgow Coma Scale: severe traumatic brain injury group (STBI, GCS less than or equal to 8) and moderate traumatic brain injury group (MTBI, GCS larger than 8).Samples of venous blood were collected in the morning at rest from 15 healthy volunteers (control group)and within 24 h after traumatic brain injury from these patients for AVP determinations by radioimmunoassay. The severity and duration of the brain edema were estimated by head CT scan. RESULTS: Plasma AVP levels (ng/L) were (mean+/-SD): control, 3.06+/-1.49; MTBI, 38.12+/-7.25; and STBI, 66.61+/-17.10.The plasma level of AVP was significantly increased within 24 h after traumatic brain injury and followed by the reduction of GCS, suggesting the deterioration of cerebral injury (P less than 0.01). And the AVP level was correlated with the severity (STBI r equal to 0.919, P less than 0.01; MTBI r equal to 0.724, P less than 0.01) and the duration of brain edema (STBI r equal to 0.790, P less than 0.01; MTBI r equal to 0.712, P less than 0.01). CONCLUSIONS: The plasma AVP level is closely associated with the severity of traumatic brain injury. AVP may play an important role in pathogenesis of brain edema after traumatic brain injury. |
| Keywords: | Argipressin Brain injuries Brain edema |
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