疏血通注射液联合西比灵治疗椎-基底动脉供血不足性眩晕55例疗效观察

目的观察疏血通注射液联合西比灵治疗椎-基底动脉供血不足性眩晕的临床疗效。方法将110例椎-基底动脉供血不足性眩晕患者随机分为2组。治疗组55例予疏血通注射液4mL加入0.9%氯化钠注射液250mL,每日1次静脉滴注;西比灵5mg,每日睡前服。对照组55例采用丹参注射液20mL加入0.9%氯化钠注射液250mL,每日1次静脉滴注。14日后评定2组临床疗效,观察2组药物起效时间、经颅多普勒超声(TCD)改善情况。结果治疗组总有效率92.73%,对照组总有效率72.73%,2组比较差异有统计学意义(P<0.05);2组药物起效时间比较差异有统计学意义(P<0.01),治疗组用药后起效早于对照组;治疗组治疗前后双侧椎动脉(VA)和基底动脉(BA)平均血流速度变化比较差异均有统计学意义(P<0.01),与对照组治疗后比较差异均有统计学意义(P<0.01),治疗组优于对照组。结论疏血通注射液联合西比灵治疗椎-基底动脉供血不足性眩晕疗效确切。

Therapeutic effects of Shuxuetong injection combined with flunarizine on 35 cases with vertigo induced by vertebra basilar insufficiency

Objective To observe the therapeutic effects of Shuxuetong injection combined with Flunarizine on patients with vertigo induced by vertebra basilar insufficiency.Methods 110 cases with vertigo were randomly divided into 2 groups.The 55 in treatment group were treated by Shuxuetong injection and Flunarizine.0.9% sodium chloride injection 250 mL with Shuxuetong 4 mL was given once a day,Flunarizine 5 mg was taken before sleep.The other 55 in control group were treated by Danshen(root of red salvia) injection.0.9 sodium chloride injection 250 mL with Danshen injection 20 mL was given once a day.The effects were recorded 14 days later.The onset time of drugs and the improvement with TCD(Trans-cranial Doppler) were recorded.Results The total effective rate in treatment group and control group was 92.73% and 72.73 respectively(P<0.05).The onset time of drugs in treatment group was earlier than that in control group(P<0.01).The alteration of average velocity of blood in bilateral vertebral artery and basilar artery was different before and after the treatment in treatment group(P<0.01).There was also a significant difference between treatment group and control group,treatment group was superior to the control one(P<0.01).Conclusion Shuxuetong injection combined with Flunarizine has an obvious therapeutic effects on vertigos induced by vertebra basilar insufficiency.