Greater seasonal cycling of 25-hydroxyvitamin D is associated with increased parathyroid hormone and bone resorption |
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Authors: | A. L. Darling K. H. Hart M. A. Gibbs F. Gossiel T. Kantermann K. Horton S. Johnsen J. L. Berry D. J. Skene R. Eastell R. Vieth S. A. Lanham-New |
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Affiliation: | 1. Department of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK 9. Department of Nutrition and Metabolism, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK 2. Bone Biochemistry Laboratory, Department of Human Metabolism, University of Sheffield, Sheffield, S10 2RX, UK 3. Chronobiology, Centre for Behaviour and Neurosciences, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands 4. School of Health and Social Care, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7TE, UK 5. Surrey Clinical Research Centre, University of Surrey, Guildford, Surrey, GU2 7XH, UK 6. Specialist Assay Laboratory (Vitamin D) and Manchester Academic Health Sciences Centre, Manchester Royal Infirmary, Manchester, M13 9WL, UK 7. Chronobiology, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK 8. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave., Toronto, ON, M5G 1X5, Canada
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Abstract: | Summary This analysis assessed whether seasonal change in 25-hydroxyvitamin D concentration was associated with bone resorption, as evidenced by serum parathyroid hormone and C-terminal telopeptide concentrations. The main finding was that increased seasonal fluctuation in 25-hydroxyvitamin D was associated with increased levels of parathyroid hormone and C-terminal telopeptide. Introduction It is established that adequate 25-hydroxyvitamin D (25(OH)D, vitamin D) concentration is required for healthy bone mineralisation. It is unknown whether seasonal fluctuations in 25(OH)D also impact on bone health. If large seasonal fluctuations in 25(OH)D were associated with increased bone resorption, this would suggest a detriment to bone health. Therefore, this analysis assessed whether there is an association between seasonal variation in 25(OH)D and bone resorption. Methods The participants were (n?=?279) Caucasian and (n?=?88) South Asian women (mean (±SD); age 48.2 years (14.4)) who participated in the longitudinal Diet, Food Intake, Nutrition and Exposure to the Sun in Southern England study (2006–2007). The main outcomes were serum 25(OH)D, serum parathyroid hormone (sPTH) and serum C-terminal telopeptide of collagen (sCTX), sampled once per season for each participant. Results Non-linear mixed modelling showed the (amplitude/mesor) ratio for seasonal change in log 25(OH)D to be predictive of log sPTH (estimate?=?0.057, 95 % CI (0.051, 0.063), p?0.0001). Therefore, individuals with a higher seasonal change in log 25(OH)D, adjusted for overall log 25(OH)D concentration, showed increased levels of log sPTH. There was a corresponding significant ability to predict the range of seasonal change in log 25(OH)D through the level of sCTX. Here, the corresponding parameter statistics were estimate?=?0.528, 95 % CI (0.418, 0.638) and p?≤?0.0001. Conclusions These findings suggest a possible detriment to bone health via increased levels of sPTH and sCTX in individuals with a larger seasonal change in 25(OH)D concentration. Further larger cohort studies are required to further investigate these preliminary findings. |
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