| 6—甲基—8—氰甲基黄酮的合成 |
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| 引用本文： | 李敬芬,毛桂洁,缪月英.6—甲基—8—氰甲基黄酮的合成[J].黑龙江医药科学,2002,25(1):15-16. |
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| 作者姓名： | 李敬芬 毛桂洁 缪月英 |
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| 作者单位： | 1. 佳木斯大学化学与药学院,黑龙江,佳木斯,154007
2. 黑龙江大学化学化工学院,黑龙江,哈尔滨,154000 |
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| 摘 要： | 目的：黄酮醋酸类化合中间体合成方法的研究。方法：通过酰基化、Fries重排、氯甲基化、氰化、缩合，氧化等六步反应完成合成。结果：采用新方法合成了未见文献报道的新化合物6－甲基－8－氰甲基黄酮。结论：该方法为合成新的黄酮醋酸类合物的方法。并且具有反应时间短、操作简便、收率好等优点。
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| 关 键 词： | 对甲基苯酚 6－甲基－8－氰甲基黄酮 FAA 抗肿瘤药 黄酮醋酸类化合物中间体 合成 |
| 文章编号： | 1008-0104(2002)01-0015-01 |
| 修稿时间： | 2001年10月26 |
Synthesis of 6-Methyl-8-Cyanmethyl Flavone |
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| LI Jingfen,MAO Guijie,MIAO Yueying.Synthesis of 6-Methyl-8-Cyanmethyl Flavone[J].Heilongjiang Medicine and Pharmacy,2002,25(1):15-16. |
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| Authors: | LI Jingfen MAO Guijie MIAO Yueying |
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| Abstract: | Objective: To study the synthetic methods of the intermediate products of the substituted flavone-8-acetic acids. Methods: The synthesis was finished by using a new six-step method including acylation, Fries rearrangement reaction, chloromethylating, cyanating, condensation reaction, and oxidization. Result: A new compound , 6-methyl-8-cyanmethylflavone was synthesized ,which has not been reported yet. Conclusions: As compared with other synthetic methods of flavones, this method is charactered of the reaction time short, the operation process simple and the yield good. |
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| Keywords: | p-methylphenol 6-methyl-8-cyanmethylflavone |
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