Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma |
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| Authors: | Bhavna Rani;Yuan Cao;Andrea Malfettone;Ciprian Tomuleasa;Isabel Fabregat;Gianluigi Giannelli; |
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| Institution: | Bhavna Rani;Yuan Cao;Andrea Malfettone;Ciprian Tomuleasa;Isabel Fabregat;Gianluigi Giannelli;Department of Medical Biosciences and Human Oncology,Padiglione Semeiotica Medica,70124 Bari,Italy;Bellvitge Biomedical Research Institute (IDIBELL),08028 Barcelona,Spain;Department of Hematology,Center for Genomics and Translational Medicine,Iuliu Hatieganu University of Medicine and Pharmacy,400012 Cluj Napoca,Romania;Department of Physiological Sciences Ⅱ,University of Barcelona,08028 Barcelona,Spain; |
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| Abstract: | Hepatocellular carcinoma is difficult to treat, primarily because the underlying molecular mechanisms driving clinical outcome are still poorly understood. Growing evidence suggests that the tissue microenvironment has a role in the biological behavior of the tumor. The main clinical issue is to identify the best target for therapeutic approaches. Here, we discuss the hypothesis that the entire tissue microenvironment might be considered as a biological target. However, the tissue microenvironment consists of several cellular and biochemical components, each of which displays a distinct biological activity. We discuss the major components of this environment and consider how they may interact to promote tumor/host crosstalk. |
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| Keywords: | Tissue microenvironment Hepatocellular carcinoma Transforming growth factor-beta Laminin-5 Cancer stem cells Therapy Target therapy |
| 本文献已被 CNKI 等数据库收录！ |
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