| 抗Jo-1抗体与皮肌炎和多发性肌炎临床关系的探讨 |
| |
| 引用本文： | 张佩莲,李晓岚,邓丹琪,周晓鸿,谢红,付萍,郭芸,王晓云,姜福琼,冒长峙.抗Jo-1抗体与皮肌炎和多发性肌炎临床关系的探讨[J].皮肤病与性病,2009,31(3):3-5. |
| |
| 作者姓名： | 张佩莲 李晓岚 邓丹琪 周晓鸿 谢红 付萍 郭芸 王晓云 姜福琼 冒长峙 |
| |
| 作者单位： | 昆明医学院第二附属医院皮肤性病/风湿免疫科,云南,昆明,650101 |
| |
| 摘 要： | 目的探讨抗Jo-1抗体与皮肌炎和多发性肌炎（PM／DM）的临床关系。方法分析16例抗Jo-1抗体阳性的多发性肌炎／皮肌炎（PM／DM）的临床特征，并与81例阴性组进行比较。结果本组中抗Jo-1抗体阳性占16．5％，抗Jo-1抗体阳性组出现肺间质病变（ILD）11例（68．75％）、肺部感染15例（93．75％）、和多关节炎／关节痛8例（50．00％）、肌肉活检异常3例（18．75％）、肌力异常4例（25．00％）、RF阳性5例（55．50％）、技工手4例（25．00％）、发热14例（87．50％）、皮肤硬肿5例（31．25％）与抗Jo-1抗体阴性组比较，差异显著（P〈0．05）。结论在多发性肌炎／皮肌炎（PM／DM）中，抗Jo—1抗体阳性者有明显的肺间质病变、肺部感染、多关节炎、RF阳性、技工手、发热、皮肤硬肿等临床特征，提高对Jo-1抗体综合征的认识，早期诊断，早期治疗，提高生存率。
|
| 关 键 词： | 抗Jo-1抗体 多发性肌炎 皮肌炎 |
Relationship between anti-Jo-1 antibody and polymyositis(PM)/dermatomyositis(DM). |
| |
| ZHANG Pei-lian,LI Xiao-lan,DENG Dan-qi,ZHOU Xiao-hong,XIE Hong,FU Ping,GUO Yun,WANG Xiao-yun,JIANG Fu-qiong,MAO chang-zhi.Relationship between anti-Jo-1 antibody and polymyositis(PM)/dermatomyositis(DM).[J].Journal of Dermatology and Venereology,2009,31(3):3-5. |
| |
| Authors: | ZHANG Pei-lian LI Xiao-lan DENG Dan-qi ZHOU Xiao-hong XIE Hong FU Ping GUO Yun WANG Xiao-yun JIANG Fu-qiong MAO chang-zhi |
| |
| Institution: | ZHANG Pei - lian , LI Xiao - lan, DENG Dan - qi, ZHOU Xiao - hong, XIE Hong , FU Ping , GUO Yun, WANG Xiao - yun, JIANG Fu - qiong, MAO chang - zhi ( Department of Dermatology ,The Second Affiliated Hospital of Kunming Medical university. Kunming 650101, China) |
| |
| Abstract: | Objective To investigate the clinical features of polymyositis （PM） / Dermatomyositis （DM） and its relationship with anti - Jo - 1 antibody. Methods Clinical characteristics of 16 PM/DM cases with anti Jo - 1 antibody were compared with that of 81 PM/DM ca- ses without anti Jo - 1 antibody. Results In Anti Jo - 1 antibody positive group, palmorary infections were most frequently presented （ 93.75 % ）, followed by fever （ 87.50% ）, interstitial pneumonia（ 68.75 % ） , arthritis （ 55.50% ）, RF positive （55.50%）, swollen skin （31.25%）, muscle weakness （25.00%）, mechanic＇ s hand （25.00%）, abnormal muscle biopsy（ 18.75% ）, and it was significantly different for these features when compared with those of anti Jo - 1 antibody negative group. Conclusion Anti Jo - 1 antibody was showed to be associated with some clinical features of PM/DM. |
| |
| Keywords: | Anti Jo -1 antibody Polymyositis Dermatomyositis |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
