| 慢性应激对大鼠海马神经元睫状神经营养因子及其mRNA表达水平的影响 |
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| 引用本文： | 王雪琦,路长林,侍坚,邓小华,何成. 慢性应激对大鼠海马神经元睫状神经营养因子及其mRNA表达水平的影响[J]. 中国药理学通报, 2002, 18(6): 626-628 |
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| 作者姓名： | 王雪琦 路长林 侍坚 邓小华 何成 |
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| 作者单位： | 第二军医大学神经生物学教研室,上海,200433 |
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| 基金项目： | 全军医学科研“十五”计划青年基金资助课题 No 0 1Q0 94，全军医学科研“十五”计划重点基金资助课题 No 0 1Z0 65，国家自然科学基金重点项目资助课题 No 39930 0 80 |
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| 摘 要： | 目的 观察慢性应激对大鼠海马神经元CNTF及其mRNA表达水平的变化。方法 采用慢性不可预见性中等强度应激 ,运用旷场实验观察大鼠行为 ;运用免疫组化和原位杂交的方法 ,观察大鼠海马神经元CNTF及其mRNA表达水平的变化。结果 与对照组相比 ,慢性应激组大鼠海马CNTF免疫阳性颗粒数目减少 ,着色浅淡 ;CNTFmRNA杂交阳性信号减少。结论 慢性应激可造成大鼠海马神经元CNTF及其mRNA表达水平降低
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| 关 键 词： | 应激 大鼠 海马 睫状神经营养因子 |
| 文章编号： | 1001-1978(2002)06-0626-03 |
| 修稿时间： | 2002-03-13 |
The influence of chronic stress on the level of CNTF and CNTF mRNA in hippocampal neurons of rats |
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| WANG Xue Qi,LU Chang Lin,SHI Jian,DENG Xiao Hua,HE Cheng. The influence of chronic stress on the level of CNTF and CNTF mRNA in hippocampal neurons of rats[J]. Chinese Pharmacological Bulletin, 2002, 18(6): 626-628 |
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| Authors: | WANG Xue Qi LU Chang Lin SHI Jian DENG Xiao Hua HE Cheng |
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| Abstract: | AIM To study the influence of chronic stress on the level of CNTF and CNTF mRNA in hippocampal neurons of rats. METHODS The chronic stress model was established by chronic unpredictable mild stress, openfield test was performed to detect the behavior of rats. Immunohistochemistry and in situ hybridization were used to observe the level of CNTF and CNTF mRNA. RESULTS Compared to control group, the CNTF like immunoreactivity and signals of CNTF mRNA in situ hybridization in the hippocampal neurons of chronic stress group were significantly decreased. CONCLUSION These results show that chronic stress can significantly decrease the level of CNTF and CNTF mRNA in the hippocampal neurons of rats. |
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| Keywords: | stress rat hippocampus CNTF |
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