术前动脉插管化疗对膀胱移行细胞癌c-myc 蛋白表达及预后的影响

目的探讨术前腹壁下动脉插管化疗对膀胱移行细胞癌c-myc蛋白表达及预后的影响.方法对化疗组膀胱癌患者44例先行盆腔区域化疗,再行开放手术;对照组68例行单纯开放手术.采集肿瘤标本,行c-myc蛋白免疫组化染色,检测癌基因蛋白的表达,同时比较随访资料.结果化疗组c-myc蛋白表达阳性率为45.5%,对照组为69.1%,两组比较P＜0.05,术前动脉插管化疗降低T2～T4膀胱移行细胞癌的c-myc蛋白表达阳性率.化疗组3年复发率为20.5%,5年生存率为79.5%,10年生存率为52.3%;对照组3年复发率为58.8%,5年生存率为47.1%,10年生存率为25.0%.结论术前动脉化疗降低膀胱移行细胞癌c-myc蛋白表达,提高膀胱移行细胞癌患者的生存率,降低复发率.

Influence of preoperative arterial chemotherapy on the expression of c-myc in transitional cell carcinoma of the bladder

Objective:To observe the influence of preoperative arterial chemotherapy on c-myc oncoprotein expression in transitional cell carcinoma of bladder and the prognosis of bladder cancer patients.Methods:112 patients with an initial diagnosis of bladder cancer were investigated. 44 surgical specimens comes from the patients who underwent preoperative arterial chemotherapy ;68 specimens came from mere operation patients; 8 specimens from human normal bladder tissue. all specimens were stained by SP immunohistochemical method to detect the expression of c-myc oncoprotein.Results:The expression of c-myc oncoprotein was closely associated with the clinical stages(P< 0.05 ); the c-myc oncoprotein positive rate was 45.5 % in the group of preoperative arterial chemotherapy; and it was 69.1 % in contrast group; c-myc oncoprotein of the normal bladder tissue was not expressed. The recurrence rate of three years, survival rate of five years and ten years were 20.5 %, 79.5 % and 52.3 % respectively in preoperative arterial chemotherapy group; and those were 58.8 %, 47.1 % and 25.0 % respectively in constrast group.Conclusions:Preoperative arterial chemotherapy can decrease the c-myc oncoprotein positive rate in transitional cell carcinoma of bladder , increase the survival rate and decrease the recurrence rate of bladder cancer patients.