1433例系统性红斑狼疮患者治疗转归的预后因素分析

目的了解系统性红斑狼疮(SLE)治疗结局的影响因素。方法采用描述性预后研究，通过单因素和多因素logistic回归对1433例系统性红斑狼疮患者的临床特征、实验室检查与疾病的预后进行分析。结果单因素分析显示发热、心动过速、呼吸加快、收缩压升高和舒张压升高、抗核抗体、抗ds—DNA抗体，补体C3降低、C反应蛋白阳性、SLE复发、起病急、胸膜炎、神经系统异常和并发器质性脑综合征与SLE预后在统计学上差异有显著性。多因素logistic回归分析显示与SLE患者的治疗结局有关的检验指标为心动过速、舒张压升高、补体C3降低、抗ds—DNA抗体、SLE复发、并发器质性脑综合征，其OR值分别为2．28、2．34、2．42、2．47、1．98和5．56。结论SLE患者的临床表现及实验室检查结果多样，心动过速、舒张压升高、补体C3降低、抗ds—DNA抗体阳性、SLE复发和并发器质性脑综合征对SLE的治疗结果有一定的不利影响，但对SLE预后的判断需综合考虑。

Study on the clinical epidemiology of systemic lupus erythematosus among 1433 cases

Objective To explore factors that affecting the outcome of systemic lupus erythematosus (SLE) therapy. Methods Factors on the results of therapy were analysed through a case-control study. Results The common symptoms of SLE were fever, joint pain and skin eruption on face while the common provocation factors of SLE were infection and birth. Through multivariate logistic regression analyses, factors that influencing SLE result of treatment were tachycardia,diastolic pressure step-up,complement C 3 reduction,anti-ds-DNA antibody,SLE relapse and brain syndrome with the OR values as 2.28 , 2.34 , 2.42 , 2.47 , 1.98 and 5.56 ,respectively. Conclusion The symptom and clinical characteristics of SLE were complicated. SLE treatment result could be influenced by tachycardia,diastolic pressure step-up,complement C 3 reduction,anti-ds-DNA antibody,SLE relapse and brain syndrome suggesting that the prognosis of SLE patients should be comprehensively considered.